TY  - JOUR
N1  - cited By 200
TI  - Ionic liquids as a potential tool for drug delivery systems
SP  - 1881
AV  - none
EP  - 1897
PB  - Royal Society of Chemistry
SN  - 20402503
IS  - 10
N2  - The pharmaceutical industries face a series of challenges in the delivery of many newly developed drug molecules because of their low solubility, bioavailability, stability and polymorphic conversion. These limitations are further exacerbated when drug molecules are insoluble or sparingly soluble in water and most pharmaceutically accepted organic solvents. To address these limitations, innovation is required in the pharmaceutical sciences for the formulation of drugs, solvents or systems for effective drug delivery. Fortunately, in the past few years, ionic liquids (ILs) - a novel class of environmentally benign and tailor-made solvents - have been increasingly exploited as solvents, co-solvents and/or materials in the fields of pharmaceutical drug delivery and active pharmaceutical ingredient (API) formulation because of their unique and tunable physicochemical and biological properties. The use of ILs can markedly improve the pharmacokinetic and pharmacodynamic properties of drugs. To highlight the potential of ILs as a drug delivery/formulation tool, this review gives an overview of the application of ILs to address critical pharmaceutical challenges, including the low solubility, polymorphism and bioavailability of drugs. This review is not intended to be comprehensive, but rather to present the efforts made in using ILs in drug solubility, API formulation and drug delivery, including topical, transdermal and oral delivery, with particular emphasis on recent developments. © 2016 The Royal Society of Chemistry.
ID  - scholars7804
KW  - 4 hydroxycoumarin; acetylcholine; acetylcysteine; aciclovir; albendazole; ammonia; caffeine; cefadroxil; choline; cinnarizine; coumarin; curcumin; danazol; dantrolene; dopamine; erythromycin; etodolac; fluorouracil; glibenclamide; ibuprofen; imidazole derivative; ionic liquid; isoniazid; itraconazole; methotrexate; paracetamol; phosphonium derivative; pyrazinamide; pyridinium derivative; unindexed drug
KW  -  biodegradability; chemical interaction; cytotoxicity; drug binding; drug delivery system; drug formulation; drug solubility; ecotoxicity; human; hydrophobicity; microemulsion; nonhuman; oral drug administration; physical chemistry; priority journal; Review; topical drug administration; transdermal drug administration
A1  - Adawiyah, N.
A1  - Moniruzzaman, M.
A1  - Hawatulaila, S.
A1  - Goto, M.
JF  - MedChemComm
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-84991372911&doi=10.1039%2fc6md00358c&partnerID=40&md5=e1ddf423e906d4c16095387f026e3d43
VL  - 7
Y1  - 2016///
ER  -