%P 1141-1148 %T Framework for Ecotoxicological Risk Assessment of Ionic Liquids %A M.I. Khan %A D. Zaini %A A.M. Shariff %A M. Moniruzzaman %I Elsevier Ltd %V 148 %O cited By 18; Conference of 4th International Conference on Process Engineering and Advanced Materials, ICPEAM 2016 ; Conference Date: 15 August 2016 Through 17 August 2016; Conference Code:131138 %L scholars7504 %J Procedia Engineering %D 2016 %R 10.1016/j.proeng.2016.06.567 %K Aquatic organisms; Computational chemistry; Ionic liquids; Iterative methods; Liquids; Process engineering; Toxicity, Aquatic ecotoxicity; Aquatic risk assessment; Design and Development; Ecotoxicological risk assessment; Methodological frameworks; Predicted environmental concentrations; Predicted no-effect concentrations; Quantitative structure-activity relationships, Risk assessment %X Although ionic liquids (ILs) hold salient features and considered as a replacement of conventional organic solvents, but their possible toxicological and ecotoxicological impacts must be considered equally in the design and development stage. Predicted no-effect concentration (PNEC) plays a vital role in assessing the ecotoxicological hazards in the ILs. A systematic methodological framework is presented for assessing the predicted environmental concentration (PEC) of ionic liquids. Initially, an effect level is predicted with a general quantitative structure-activity relationship (QSAR). Secondly, predicted no-effect concentration (PNEC) is calculated by using assessment factor (AF). The PEC is compared to the PNEC to characterize the risk for the freshwater aquatic organisms. If the ratio continued to exceed one, ionic liquids under investigation will need further aquatic risk assessment procedures, which involve iterative steps to refine the PEC and PNEC. © 2016 The Authors.