eprintid: 7448
rev_number: 2
eprint_status: archive
userid: 1
dir: disk0/00/00/74/48
datestamp: 2023-11-09 16:19:15
lastmod: 2023-11-09 16:19:15
status_changed: 2023-11-09 16:09:24
type: conference_item
metadata_visibility: show
creators_name: Humayun, H.Y.
creators_name: Shaarani, M.N.N.M.
creators_name: Warrior, A.
creators_name: Abdullah, B.
creators_name: Salam, M.A.
title: The Effect of Co-solvent on the Solubility of a Sparingly Soluble Crystal of Benzoic Acid
ispublished: pub
keywords: Cobalt; Dissociation; Food preservatives; Free energy; Gibbs free energy; Glycerol; Process engineering; Solubility; Solvents; Temperature; Thermodynamics, Aqueous solubility; Cosolvents; Dissociation constant; Dissociation process; Dissolution rates; Pharmaceutical industry; Sparingly Soluble; Temperature increase, Benzoic acid
note: cited By 8; Conference of 4th International Conference on Process Engineering and Advanced Materials, ICPEAM 2016 ; Conference Date: 15 August 2016 Through 17 August 2016; Conference Code:131138
abstract: The Benzoic acid is widely used in the pharmaceutical industry, plasticizers and food preservative which show low aqueous solubility and dissolution rate. The investigation has been made to improve the solubility of benzoic acid by using co-solvent. The co-solvent solution is prepared by using glycerol in water by volume ratio. The result shows the relation between solubility in different co-solvent and temperature whereby as the percentage of glycerol increase, the solubility of benzoic acid increase. A similartrend was depicted in term of solubility relation with temperature as the temperature increase amount of benzoic acid dissolved also increase. Thermodynamics dissociation constant, pKa are directly proportional totemperature between 30oC and 90oC. Enthalpy and entropy change of the dissociation process are 2.907 kJ/mole and -24.09 J/mole respectively. Gibbs free energy of dissociation at 30oC, 60oC and 90oC are -4.390 KJ/mole, -5.114 KJ/mole and 5.837 KJ/mole respectively depicted that the solubility increased with temperature. © 2016 The Authors.
date: 2016
publisher: Elsevier Ltd
official_url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85013963359&doi=10.1016%2fj.proeng.2016.06.548&partnerID=40&md5=01a89419cb8c4c5e31ebfa8934f5a9dc
id_number: 10.1016/j.proeng.2016.06.548
full_text_status: none
publication: Procedia Engineering
volume: 148
pagerange: 1320-1325
refereed: TRUE
issn: 18777058
citation:   Humayun, H.Y. and Shaarani, M.N.N.M. and Warrior, A. and Abdullah, B. and Salam, M.A.  (2016) The Effect of Co-solvent on the Solubility of a Sparingly Soluble Crystal of Benzoic Acid.  In: UNSPECIFIED.