eprintid: 7050
rev_number: 2
eprint_status: archive
userid: 1
dir: disk0/00/00/70/50
datestamp: 2023-11-09 16:18:51
lastmod: 2023-11-09 16:18:51
status_changed: 2023-11-09 16:08:21
type: article
metadata_visibility: show
creators_name: Khan, F.U.
creators_name: Khan, A.-U.
creators_name: Hussain, J.
creators_name: Khan, I.U.
creators_name: Muhammad, N.
creators_name: Khan, A.
creators_name: Mehmood, S.
creators_name: Asiri, A.M.
creators_name: Khan, S.B.
creators_name: Gilani, A.H.
title: Spasmolytic and Ca++ channel blocking potential of nepetolide: Isolated from nepeta suavis
ispublished: pub
keywords: calcium channel blocking agent; nepetolide; potassium; spasmolytic agent; unclassified drug; verapamil; calcium channel blocking agent; cholinergic receptor blocking agent; diterpene; nepetolide, Article; concentration response; controlled study; drug isolation; drug screening; drug structure; muscle contraction; Nepeta; Nepeta suavis; Oryctolagus cuniculus; spasmolysis; structure activity relation; structure analysis; animal; chemistry; drug effects; in vitro study; isolation and purification; jejunum; rabbit, Animals; Calcium Channel Blockers; Diterpenes; In Vitro Techniques; Jejunum; Nepeta; Parasympatholytics; Rabbits
note: cited By 1
abstract: Nepeta suavis is used in traditional medicine for treatment of abdominal spasm (colic). The tricyclic clerodane type diterpene, nepetolide, isolated for the first time from Nepeta suavis, was evaluated for Ca++ antagonist and antispasmodic activities. When studied in isolated rabbit jejunum, nepetolide caused concentration-dependent (0.03-100 μM) relaxation of spontaneous and high K+ (80 mM)-induced contractions, like that caused by verapamil, indicating that nepetolide exhibits spasmolytic activity, possibly mediated through Ca++ channel blocking action, which provides scientific explanation for the medicinal application of Nepeta suavis as an antispasmodic agent.
date: 2016
publisher: Natural Product Incorporation
official_url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84982145175&doi=10.1177%2f1934578x1601100507&partnerID=40&md5=85318b65a115e6396bc0d19a401068c4
id_number: 10.1177/1934578x1601100507
full_text_status: none
publication: Natural Product Communications
volume: 11
number: 5
pagerange: 591-592
refereed: TRUE
issn: 1934578X
citation:   Khan, F.U. and Khan, A.-U. and Hussain, J. and Khan, I.U. and Muhammad, N. and Khan, A. and Mehmood, S. and Asiri, A.M. and Khan, S.B. and Gilani, A.H.  (2016) Spasmolytic and Ca++ channel blocking potential of nepetolide: Isolated from nepeta suavis.  Natural Product Communications, 11 (5).  pp. 591-592.  ISSN 1934578X