TY  - JOUR
PB  - Natural Product Incorporation
SP  - 591
AV  - none
ID  - scholars7050
EP  - 592
N2  - Nepeta suavis is used in traditional medicine for treatment of abdominal spasm (colic). The tricyclic clerodane type diterpene, nepetolide, isolated for the first time from Nepeta suavis, was evaluated for Ca++ antagonist and antispasmodic activities. When studied in isolated rabbit jejunum, nepetolide caused concentration-dependent (0.03-100 μM) relaxation of spontaneous and high K+ (80 mM)-induced contractions, like that caused by verapamil, indicating that nepetolide exhibits spasmolytic activity, possibly mediated through Ca++ channel blocking action, which provides scientific explanation for the medicinal application of Nepeta suavis as an antispasmodic agent.
SN  - 1934578X
IS  - 5
KW  - calcium channel blocking agent; nepetolide; potassium; spasmolytic agent; unclassified drug; verapamil; calcium channel blocking agent; cholinergic receptor blocking agent; diterpene; nepetolide
KW  -  Article; concentration response; controlled study; drug isolation; drug screening; drug structure; muscle contraction; Nepeta; Nepeta suavis; Oryctolagus cuniculus; spasmolysis; structure activity relation; structure analysis; animal; chemistry; drug effects; in vitro study; isolation and purification; jejunum; rabbit
KW  -  Animals; Calcium Channel Blockers; Diterpenes; In Vitro Techniques; Jejunum; Nepeta; Parasympatholytics; Rabbits
TI  - Spasmolytic and Ca++ channel blocking potential of nepetolide: Isolated from nepeta suavis
VL  - 11
JF  - Natural Product Communications
A1  - Khan, F.U.
A1  - Khan, A.-U.
A1  - Hussain, J.
A1  - Khan, I.U.
A1  - Muhammad, N.
A1  - Khan, A.
A1  - Mehmood, S.
A1  - Asiri, A.M.
A1  - Khan, S.B.
A1  - Gilani, A.H.
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-84982145175&doi=10.1177%2f1934578x1601100507&partnerID=40&md5=85318b65a115e6396bc0d19a401068c4
N1  - cited By 1
Y1  - 2016///
ER  -