relation: https://khub.utp.edu.my/scholars/7050/
title: Spasmolytic and Ca++ channel blocking potential of nepetolide: Isolated from nepeta suavis
creator: Khan, F.U.
creator: Khan, A.-U.
creator: Hussain, J.
creator: Khan, I.U.
creator: Muhammad, N.
creator: Khan, A.
creator: Mehmood, S.
creator: Asiri, A.M.
creator: Khan, S.B.
creator: Gilani, A.H.
description: Nepeta suavis is used in traditional medicine for treatment of abdominal spasm (colic). The tricyclic clerodane type diterpene, nepetolide, isolated for the first time from Nepeta suavis, was evaluated for Ca++ antagonist and antispasmodic activities. When studied in isolated rabbit jejunum, nepetolide caused concentration-dependent (0.03-100 μM) relaxation of spontaneous and high K+ (80 mM)-induced contractions, like that caused by verapamil, indicating that nepetolide exhibits spasmolytic activity, possibly mediated through Ca++ channel blocking action, which provides scientific explanation for the medicinal application of Nepeta suavis as an antispasmodic agent.
publisher: Natural Product Incorporation
date: 2016
type: Article
type: PeerReviewed
identifier:   Khan, F.U. and Khan, A.-U. and Hussain, J. and Khan, I.U. and Muhammad, N. and Khan, A. and Mehmood, S. and Asiri, A.M. and Khan, S.B. and Gilani, A.H.  (2016) Spasmolytic and Ca++ channel blocking potential of nepetolide: Isolated from nepeta suavis.  Natural Product Communications, 11 (5).  pp. 591-592.  ISSN 1934578X     
relation: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84982145175&doi=10.1177%2f1934578x1601100507&partnerID=40&md5=85318b65a115e6396bc0d19a401068c4
relation: 10.1177/1934578x1601100507
identifier: 10.1177/1934578x1601100507