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primary topic: Recent advances in exploiting ionic liquids for biomolecules: Solubility, stability and applications

Recent advances in exploiting ionic liquids for biomolecules: Solubility, stability and applications
type: AcademicArticle
type: Article
abstract: The technological utility of biomolecules (e.g. proteins, enzymes and DNA) can be significantly enhanced by combining them with ionic liquids (ILs) â�� potentially attractive â��greenâ�� and â��designerâ�� solvents â�� rather than using in conventional organic solvents or water. In recent years, ILs have been used as solvents, cosolvents, and reagents for biocatalysis, biotransformation, protein preservation and stabilization, DNA solubilization and stabilization, and other biomolecule-based applications. Using ILs can dramatically enhance the structural and chemical stability of proteins, DNA, and enzymes. This article reviews the recent technological developments of ILs in protein-, enzyme-, and DNA-based applications. We discuss the different routes to increase biomolecule stability and activity in ILs, and the design of biomolecule-friendly ILs that can dissolve biomolecules with minimum alteration to their structure. This information will be helpful to design IL-based processes in biotechnology and the biological sciences that can serve as novel and selective processes for enzymatic reactions, protein and DNA stability, and other biomolecule-based applications. Copyright © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
date: 2016
volume: 11
issue: 8
is part of: Biotechnology Journal
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository

Wiley-VCH Verlag
type: Organization

Biotechnology Journal
type: Collection
issn: 18606768

M. Goto
type: Person
given name: M.
family name: Goto

M. Moniruzzaman
type: Person
given name: M.
family name: Moniruzzaman

M. Sivapragasam
type: Person
given name: M.
family name: Sivapragasam

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primary topic: Recent advances in exploiting ionic liquids for biomolecules: Solubility, stability and applications