<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Ionic liquid-mediated transcutaneous protein delivery with solid-in-oil nanodispersions"^^ . "As a potentially safe and non-invasive vaccination method, transcutaneous immunization represents an attractive alternative to conventional vaccine delivery by injection. However, the development of transcutaneous immunization has remained a challenge for a large number of hydrophilic macromolecules including protein and peptide antigens. We report a novel ionic liquid (IL)-mediated transcutaneous vaccine formulation consisting of a solid-in-oil (S/O) nanodispersion of antigen coated with pharmaceutically accepted surfactants dispersed in IL-containing oil. The introduction of the IL C12mimTf2N (1-dodecyl-3-methyl imidazolium bis(trifluoromethyl sulfonyl) amide) as a penetration enhancer in the formulation significantly enhanced the skin permeability of ovalbumin (OVA), a model antigen. It was also found that the IL-mediated S/O nanodispersion obtained high levels of OVA-specific serum IgG compared with both S/O nanodispersions without IL and PBS control. These findings clearly indicate that ILs-which are potentially attractive \"green\" and \"designer\" solvents-could serve as potential skin penetration enhancers in transcutaneous vaccination for hydrophilic macromolecules. © 2015 The Royal Society of Chemistry."^^ . "2015" . . "6" . "12" . . "Royal Society of Chemistry"^^ . . . "MedChemComm"^^ . . . "20402503" . . . . . . . . . . . . . . . . . . . "N."^^ . "Kamiya"^^ . "N. Kamiya"^^ . . "M."^^ . "Moniruzzaman"^^ . "M. Moniruzzaman"^^ . . "S."^^ . "Araki"^^ . "S. Araki"^^ . . "M."^^ . "Goto"^^ . "M. Goto"^^ . . "R."^^ . "Wakabayashi"^^ . "R. Wakabayashi"^^ . . . . . "HTML Summary of #6211 \n\nIonic liquid-mediated transcutaneous protein delivery with solid-in-oil nanodispersions\n\n" . "text/html" . .