TY  - JOUR
AV  - none
PB  - Blackwell Publishing
SP  - 285
EP  - 289
ID  - scholars5635
KW  - tacrolimus; immunosuppressive agent
KW  -  adolescent; adult; aged; Article; computerised digital imaging system; digital imaging; drug response; female; human; major clinical study; male; open study; physician global assessment; pigmentation; prospective study; skin disease assessment; vitiligo; diagnostic imaging; drug effects; image processing; middle aged; skin pigmentation; treatment outcome; vitiligo; young adult
KW  -  Adolescent; Adult; Aged; Female; Humans; Image Processing
KW  -  Computer-Assisted; Immunosuppressive Agents; Male; Middle Aged; Prospective Studies; Skin Pigmentation; Tacrolimus; Treatment Outcome; Vitiligo; Young Adult
IS  - 4
TI  - Objective assessment of vitiligo with a computerised digital imaging analysis system
N2  - An objective tool to quantify treatment response in vitiligo is currently lacking. This study aimed to objectively evaluate the treatment response in vitiligo by using a computerised digital imaging analysis system (C-DIAS) and to compare it with the physician's global assessment (PGA). Tacrolimus ointment 0.1 (Protopic; Astellas Pharma Tech,Toyama, Japan) was applied twice daily on selected lesions which were photographed every 6 weeks for 24 weeks. The primary efficacy end-point was the mean percentage of repigmentation (MPR), as assessed by the digital method (MPR-C-DIAS) or by the PGA. The response was categorised into none (0), mild (1-25), moderate (26-50), good (51-75) and excellent (76-100). MPR-C-DIAS: Out of 56 patients, 44 (79) responded. Overall, the response was mild in 22 (39), moderate in 21(40) and good in one (2) patient(s). A total of 39 (70) patients responded as measured by PGA. The repigmentation was mild in 27(48), moderate in 10 (18) and good to excellent in two (4) patients. The κ test of consistency was 0.17 (P = 0.053), which shows poor agreement between the two assessment methods, although this is not statistically significant. The C-DIAS can be used to perform an objective analysis of repigmentation or depigmentation in vitiligo skin lesions in response to treatment. © 2014 The Australasian College of Dermatologists.
SN  - 00048380
VL  - 56
JF  - Australasian Journal of Dermatology
N1  - cited By 12
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-84956547590&doi=10.1111%2fajd.12247&partnerID=40&md5=4c4f5a7c9d6eba90083c9fc89c75394f
A1  - Shamsudin, N.
A1  - Hussein, S.H.
A1  - Nugroho, H.
A1  - Ahmad Fadzil, M.H.
Y1  - 2015///
ER  -