relation: https://khub.utp.edu.my/scholars/5635/
title: Objective assessment of vitiligo with a computerised digital imaging analysis system
creator: Shamsudin, N.
creator: Hussein, S.H.
creator: Nugroho, H.
creator: Ahmad Fadzil, M.H.
description: An objective tool to quantify treatment response in vitiligo is currently lacking. This study aimed to objectively evaluate the treatment response in vitiligo by using a computerised digital imaging analysis system (C-DIAS) and to compare it with the physician's global assessment (PGA). Tacrolimus ointment 0.1 (Protopic; Astellas Pharma Tech,Toyama, Japan) was applied twice daily on selected lesions which were photographed every 6 weeks for 24 weeks. The primary efficacy end-point was the mean percentage of repigmentation (MPR), as assessed by the digital method (MPR-C-DIAS) or by the PGA. The response was categorised into none (0), mild (1-25), moderate (26-50), good (51-75) and excellent (76-100). MPR-C-DIAS: Out of 56 patients, 44 (79) responded. Overall, the response was mild in 22 (39), moderate in 21(40) and good in one (2) patient(s). A total of 39 (70) patients responded as measured by PGA. The repigmentation was mild in 27(48), moderate in 10 (18) and good to excellent in two (4) patients. The κ test of consistency was 0.17 (P = 0.053), which shows poor agreement between the two assessment methods, although this is not statistically significant. The C-DIAS can be used to perform an objective analysis of repigmentation or depigmentation in vitiligo skin lesions in response to treatment. © 2014 The Australasian College of Dermatologists.
publisher: Blackwell Publishing
date: 2015
type: Article
type: PeerReviewed
identifier:   Shamsudin, N. and Hussein, S.H. and Nugroho, H. and Ahmad Fadzil, M.H.  (2015) Objective assessment of vitiligo with a computerised digital imaging analysis system.  Australasian Journal of Dermatology, 56 (4).  pp. 285-289.  ISSN 00048380     
relation: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84956547590&doi=10.1111%2fajd.12247&partnerID=40&md5=4c4f5a7c9d6eba90083c9fc89c75394f
relation: 10.1111/ajd.12247
identifier: 10.1111/ajd.12247