eprintid: 4312
rev_number: 2
eprint_status: archive
userid: 1
dir: disk0/00/00/43/12
datestamp: 2023-11-09 16:15:59
lastmod: 2023-11-09 16:15:59
status_changed: 2023-11-09 15:58:09
type: article
metadata_visibility: show
creators_name: Khan, D.
creators_name: Khan, H.U.
creators_name: Khan, F.
creators_name: Khan, S.
creators_name: Badshah, S.
creators_name: Khan, A.S.
creators_name: Samad, A.
creators_name: Ali, F.
creators_name: Khan, I.
creators_name: Muhammad, N.
title: New cholinesterase inhibitory constituents from Lonicera quinquelocularis
ispublished: pub
keywords: acetylcholinesterase; bis(7 acetoxy 2 ethyl 5 methylheptyl)phthalate; cholinesterase; cholinesterase inhibitor; Lonicera quinquelocularis extract; neopentyl 4 ethoxy 3, 5 bis 3 methyl 2 butenyl benzoate; neopentyl 4 hydroxy 3, 5 bis 3 methyl 2 butenyl benzoate; phthalic acid bis(2 ethylhexyl) ester; phthalic acid dioctyl ester; plant extract; unclassified drug; cholinesterase inhibitor, article; cholinesterase inhibition; controlled study; dose response; drug isolation; drug structure; IC 50; Lonicera; Lonicera quinquelocularis; phytochemistry; animal; carbon nuclear magnetic resonance; chemistry; enzyme assay; horse; IC50; metabolism; proton nuclear magnetic resonance, Animals; Butyrylcholinesterase; Carbon-13 Magnetic Resonance Spectroscopy; Cholinesterase Inhibitors; Cholinesterases; Enzyme Assays; Horses; Inhibitory Concentration 50; Lonicera; Proton Magnetic Resonance Spectroscopy
note: cited By 10
abstract: A phytochemical investigation on the ethyl acetate soluble fraction of Lonicera quinquelocularis (whole plant) led to the first time isolation of one new phthalate; bis(7-acetoxy-2-ethyl-5-methylheptyl) phthalate (3) and two new benzoates; neopentyl-4- ethoxy-3, 5-bis (3-methyl-2-butenyl benzoate (4) and neopentyl-4-hydroxy-3, 5-bis (3-methyl-2-butenyl benzoate (5) along with two known compounds bis (2-ethylhexyl phthalate (1) and dioctyl phthalate (2). Their structures were established on the basis of spectroscopic analysis and by comparison with available data in the literature. All the compounds (1-5) were tested for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities in dose dependent manner. The IC50 (50 inhibitory effect) values of compounds 3 and 5 against AChE were 1.65 and 3.43 μM while the values obtained against BChE were 5.98 and 9.84 μM respectively. Compounds 2 and 4 showed weak inhibition profile. © 2014 Khan et al.
date: 2014
publisher: Public Library of Science
official_url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899660742&doi=10.1371%2fjournal.pone.0094952&partnerID=40&md5=ed42fe994686eb2503918f56166c5c5d
id_number: 10.1371/journal.pone.0094952
full_text_status: none
publication: PLoS ONE
volume: 9
number: 4
refereed: TRUE
issn: 19326203
citation:   Khan, D. and Khan, H.U. and Khan, F. and Khan, S. and Badshah, S. and Khan, A.S. and Samad, A. and Ali, F. and Khan, I. and Muhammad, N.  (2014) New cholinesterase inhibitory constituents from Lonicera quinquelocularis.  PLoS ONE, 9 (4).   ISSN 19326203