%0 Journal Article
%@ 19326203
%A Khan, D.
%A Khan, H.U.
%A Khan, F.
%A Khan, S.
%A Badshah, S.
%A Khan, A.S.
%A Samad, A.
%A Ali, F.
%A Khan, I.
%A Muhammad, N.
%D 2014
%F scholars:4312
%I Public Library of Science
%J PLoS ONE
%K acetylcholinesterase; bis(7 acetoxy 2 ethyl 5 methylheptyl)phthalate; cholinesterase; cholinesterase inhibitor; Lonicera quinquelocularis extract; neopentyl 4 ethoxy 3, 5 bis 3 methyl 2 butenyl benzoate; neopentyl 4 hydroxy 3, 5 bis 3 methyl 2 butenyl benzoate; phthalic acid bis(2 ethylhexyl) ester; phthalic acid dioctyl ester; plant extract; unclassified drug; cholinesterase inhibitor, article; cholinesterase inhibition; controlled study; dose response; drug isolation; drug structure; IC 50; Lonicera; Lonicera quinquelocularis; phytochemistry; animal; carbon nuclear magnetic resonance; chemistry; enzyme assay; horse; IC50; metabolism; proton nuclear magnetic resonance, Animals; Butyrylcholinesterase; Carbon-13 Magnetic Resonance Spectroscopy; Cholinesterase Inhibitors; Cholinesterases; Enzyme Assays; Horses; Inhibitory Concentration 50; Lonicera; Proton Magnetic Resonance Spectroscopy
%N 4
%R 10.1371/journal.pone.0094952
%T New cholinesterase inhibitory constituents from Lonicera quinquelocularis
%U https://khub.utp.edu.my/scholars/4312/
%V 9
%X A phytochemical investigation on the ethyl acetate soluble fraction of Lonicera quinquelocularis (whole plant) led to the first time isolation of one new phthalate; bis(7-acetoxy-2-ethyl-5-methylheptyl) phthalate (3) and two new benzoates; neopentyl-4- ethoxy-3, 5-bis (3-methyl-2-butenyl benzoate (4) and neopentyl-4-hydroxy-3, 5-bis (3-methyl-2-butenyl benzoate (5) along with two known compounds bis (2-ethylhexyl phthalate (1) and dioctyl phthalate (2). Their structures were established on the basis of spectroscopic analysis and by comparison with available data in the literature. All the compounds (1-5) were tested for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities in dose dependent manner. The IC50 (50 inhibitory effect) values of compounds 3 and 5 against AChE were 1.65 and 3.43 μM while the values obtained against BChE were 5.98 and 9.84 μM respectively. Compounds 2 and 4 showed weak inhibition profile. © 2014 Khan et al.
%Z cited By 10