relation: https://khub.utp.edu.my/scholars/4312/
title: New cholinesterase inhibitory constituents from Lonicera quinquelocularis
creator: Khan, D.
creator: Khan, H.U.
creator: Khan, F.
creator: Khan, S.
creator: Badshah, S.
creator: Khan, A.S.
creator: Samad, A.
creator: Ali, F.
creator: Khan, I.
creator: Muhammad, N.
description: A phytochemical investigation on the ethyl acetate soluble fraction of Lonicera quinquelocularis (whole plant) led to the first time isolation of one new phthalate; bis(7-acetoxy-2-ethyl-5-methylheptyl) phthalate (3) and two new benzoates; neopentyl-4- ethoxy-3, 5-bis (3-methyl-2-butenyl benzoate (4) and neopentyl-4-hydroxy-3, 5-bis (3-methyl-2-butenyl benzoate (5) along with two known compounds bis (2-ethylhexyl phthalate (1) and dioctyl phthalate (2). Their structures were established on the basis of spectroscopic analysis and by comparison with available data in the literature. All the compounds (1-5) were tested for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities in dose dependent manner. The IC50 (50 inhibitory effect) values of compounds 3 and 5 against AChE were 1.65 and 3.43 μM while the values obtained against BChE were 5.98 and 9.84 μM respectively. Compounds 2 and 4 showed weak inhibition profile. © 2014 Khan et al.
publisher: Public Library of Science
date: 2014
type: Article
type: PeerReviewed
identifier:   Khan, D. and Khan, H.U. and Khan, F. and Khan, S. and Badshah, S. and Khan, A.S. and Samad, A. and Ali, F. and Khan, I. and Muhammad, N.  (2014) New cholinesterase inhibitory constituents from Lonicera quinquelocularis.  PLoS ONE, 9 (4).   ISSN 19326203     
relation: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899660742&doi=10.1371%2fjournal.pone.0094952&partnerID=40&md5=ed42fe994686eb2503918f56166c5c5d
relation: 10.1371/journal.pone.0094952
identifier: 10.1371/journal.pone.0094952