<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Modeling of hyaluronic acid containing anti-cancer drugs-loaded polylactic-co-glycolic acid bioconjugates for targeted delivery to cancer cells"^^ . "Molecular modeling of hyaluronan (HA), polylactic-co-glycolic acid (PLGA), polyethylene glycol-bis-amine (PEG-bis-amine), Curcumin, Cisplatin and the conjugate HA-PEG-PLGA containing Curcumin/Cisplatin were performed using Discovery Studio 2.5 to better understand issues and constraints related to targeted delivery of potent anticancer drugs to cancer cells. HA, a versatile biopolymer is a ligand of cancer cell receptor, CD44 that can be particularly useful in a receptor-mediated cellular uptake of drug-incorporated nanoparticles. Biocompatible and biodegradable polymers, PLGA and PEG, serve as polymeric micelles for controlled-release of drug. Curcumin as a natural anticancer agent has poor solubility that limits its use in drug therapeutics, while platinum-based Cisplatin exhibits systemic cytotoxicity. These can be overcome via drug delivery in polymeric biocompatible vehicles. The PLGA-PEG-HA conjugate shows the total measurement of 105 bond length with average bond length of 1.274163 à . The conjugation between PEG and HA occurs at C8-O1 atoms and can be manipulated to improve properties. © 2012 American Institute of Physics."^^ . "2012" . . "1482" . . "AIP Conference Proceedings"^^ . . . "0094243X" . . . . . . . . . . . . . . . . . . . ""^^ . "Gul-E-Saba"^^ . " Gul-E-Saba"^^ . . "M.N."^^ . "Zafar"^^ . "M.N. Zafar"^^ . . "M.A."^^ . "Abdullah"^^ . "M.A. Abdullah"^^ . . "A."^^ . "Madthing"^^ . "A. Madthing"^^ . . "A."^^ . "Adulphakdee"^^ . "A. Adulphakdee"^^ . . . . . "HTML Summary of #2548 \n\nModeling of hyaluronic acid containing anti-cancer drugs-loaded polylactic-co-glycolic acid bioconjugates for targeted delivery to cancer cells\n\n" . "text/html" . .