eprintid: 19815
rev_number: 2
eprint_status: archive
userid: 1
dir: disk0/00/01/98/15
datestamp: 2024-06-04 14:19:33
lastmod: 2024-06-04 14:19:33
status_changed: 2024-06-04 14:15:57
type: article
metadata_visibility: show
creators_name: Nabila, F.H.
creators_name: Islam, R.
creators_name: Shimul, I.M.
creators_name: Moniruzzaman, M.
creators_name: Wakabayashi, R.
creators_name: Kamiya, N.
creators_name: Goto, M.
title: Ionic liquid-mediated ethosome for transdermal delivery of insulin
ispublished: pub
keywords: Controlled drug delivery; Ionic liquids; Targeted drug delivery, Dimyristoyl; Drug encapsulation efficiency; Ethosomes; High molecular weight; Long term stability; Phosphatidyl choline; Skin permeation; Transdermal delivery, Insulin, 1,2 dimyristoyl sn glycero 3 phosphatidylcholine; ethosome; insulin; ionic liquid; liposome; macrogol; nanoparticle; phosphatidylcholine; phospholipid; unclassified drug; dimyristoylphosphatidylcholine; drug; insulin, Article; cell viability; circular dichroism; confocal laser scanning microscopy; dispersity; drug delivery system; emulsion; encapsulation; molecular dynamics; molecular weight; particle size; phospholipid vesicle; photon correlation spectroscopy; spectrofluorometry; transmission electron microscopy; volatilization; X ray diffraction; zeta potential; cutaneous drug administration; skin, Administration, Cutaneous; Dimyristoylphosphatidylcholine; Insulin; Ionic Liquids; Liposomes; Pharmaceutical Preparations; Skin
note: cited By 0
abstract: Herein, we report ethosome (ET) formulations composed of a safe amount of 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine (DMPC)-based ionic liquid with various concentrations of ethanol as a carrier for the transdermal delivery of a high molecular weight drug, insulin. The Insulin-loaded ET vesicles exhibited long-term stability compared to conventional DMPC ETs, showing significantly higher drug encapsulation efficiency and increased skin permeation ability. © 2024 The Royal Society of Chemistry.
date: 2024
publisher: Royal Society of Chemistry
official_url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85187572294&doi=10.1039%2fd3cc06130b&partnerID=40&md5=9ee9b5685dd99741d31b962b2e09047c
id_number: 10.1039/d3cc06130b
full_text_status: none
publication: Chemical Communications
volume: 60
number: 30
pagerange: 4036-4039
refereed: TRUE
issn: 13597345
citation:   Nabila, F.H. and Islam, R. and Shimul, I.M. and Moniruzzaman, M. and Wakabayashi, R. and Kamiya, N. and Goto, M.  (2024) Ionic liquid-mediated ethosome for transdermal delivery of insulin.  Chemical Communications, 60 (30).  pp. 4036-4039.  ISSN 13597345