%R 10.1039/d3cc06130b
%N 30
%D 2024
%L scholars19815
%J Chemical Communications
%O cited By 0
%K Controlled drug delivery; Ionic liquids; Targeted drug delivery, Dimyristoyl; Drug encapsulation efficiency; Ethosomes; High molecular weight; Long term stability; Phosphatidyl choline; Skin permeation; Transdermal delivery, Insulin, 1,2 dimyristoyl sn glycero 3 phosphatidylcholine; ethosome; insulin; ionic liquid; liposome; macrogol; nanoparticle; phosphatidylcholine; phospholipid; unclassified drug; dimyristoylphosphatidylcholine; drug; insulin, Article; cell viability; circular dichroism; confocal laser scanning microscopy; dispersity; drug delivery system; emulsion; encapsulation; molecular dynamics; molecular weight; particle size; phospholipid vesicle; photon correlation spectroscopy; spectrofluorometry; transmission electron microscopy; volatilization; X ray diffraction; zeta potential; cutaneous drug administration; skin, Administration, Cutaneous; Dimyristoylphosphatidylcholine; Insulin; Ionic Liquids; Liposomes; Pharmaceutical Preparations; Skin
%X Herein, we report ethosome (ET) formulations composed of a safe amount of 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine (DMPC)-based ionic liquid with various concentrations of ethanol as a carrier for the transdermal delivery of a high molecular weight drug, insulin. The Insulin-loaded ET vesicles exhibited long-term stability compared to conventional DMPC ETs, showing significantly higher drug encapsulation efficiency and increased skin permeation ability. © 2024 The Royal Society of Chemistry.
%P 4036-4039
%I Royal Society of Chemistry
%V 60
%A F.H. Nabila
%A R. Islam
%A I.M. Shimul
%A M. Moniruzzaman
%A R. Wakabayashi
%A N. Kamiya
%A M. Goto
%T Ionic liquid-mediated ethosome for transdermal delivery of insulin