TY  - JOUR
PB  - Royal Society of Chemistry
SN  - 13597345
EP  - 4039
AV  - none
TI  - Ionic liquid-mediated ethosome for transdermal delivery of insulin
SP  - 4036
N1  - cited By 0
Y1  - 2024///
VL  - 60
JF  - Chemical Communications
A1  - Nabila, F.H.
A1  - Islam, R.
A1  - Shimul, I.M.
A1  - Moniruzzaman, M.
A1  - Wakabayashi, R.
A1  - Kamiya, N.
A1  - Goto, M.
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85187572294&doi=10.1039%2fd3cc06130b&partnerID=40&md5=9ee9b5685dd99741d31b962b2e09047c
ID  - scholars19815
KW  - Controlled drug delivery; Ionic liquids; Targeted drug delivery
KW  -  Dimyristoyl; Drug encapsulation efficiency; Ethosomes; High molecular weight; Long term stability; Phosphatidyl choline; Skin permeation; Transdermal delivery
KW  -  Insulin
KW  -  1
KW  - 2 dimyristoyl sn glycero 3 phosphatidylcholine; ethosome; insulin; ionic liquid; liposome; macrogol; nanoparticle; phosphatidylcholine; phospholipid; unclassified drug; dimyristoylphosphatidylcholine; drug; insulin
KW  -  Article; cell viability; circular dichroism; confocal laser scanning microscopy; dispersity; drug delivery system; emulsion; encapsulation; molecular dynamics; molecular weight; particle size; phospholipid vesicle; photon correlation spectroscopy; spectrofluorometry; transmission electron microscopy; volatilization; X ray diffraction; zeta potential; cutaneous drug administration; skin
KW  -  Administration
KW  -  Cutaneous; Dimyristoylphosphatidylcholine; Insulin; Ionic Liquids; Liposomes; Pharmaceutical Preparations; Skin
N2  - Herein, we report ethosome (ET) formulations composed of a safe amount of 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine (DMPC)-based ionic liquid with various concentrations of ethanol as a carrier for the transdermal delivery of a high molecular weight drug, insulin. The Insulin-loaded ET vesicles exhibited long-term stability compared to conventional DMPC ETs, showing significantly higher drug encapsulation efficiency and increased skin permeation ability. © 2024 The Royal Society of Chemistry.
IS  - 30
ER  -