@article{scholars19815, year = {2024}, journal = {Chemical Communications}, publisher = {Royal Society of Chemistry}, pages = {4036--4039}, volume = {60}, note = {cited By 0}, number = {30}, doi = {10.1039/d3cc06130b}, title = {Ionic liquid-mediated ethosome for transdermal delivery of insulin}, keywords = {Controlled drug delivery; Ionic liquids; Targeted drug delivery, Dimyristoyl; Drug encapsulation efficiency; Ethosomes; High molecular weight; Long term stability; Phosphatidyl choline; Skin permeation; Transdermal delivery, Insulin, 1,2 dimyristoyl sn glycero 3 phosphatidylcholine; ethosome; insulin; ionic liquid; liposome; macrogol; nanoparticle; phosphatidylcholine; phospholipid; unclassified drug; dimyristoylphosphatidylcholine; drug; insulin, Article; cell viability; circular dichroism; confocal laser scanning microscopy; dispersity; drug delivery system; emulsion; encapsulation; molecular dynamics; molecular weight; particle size; phospholipid vesicle; photon correlation spectroscopy; spectrofluorometry; transmission electron microscopy; volatilization; X ray diffraction; zeta potential; cutaneous drug administration; skin, Administration, Cutaneous; Dimyristoylphosphatidylcholine; Insulin; Ionic Liquids; Liposomes; Pharmaceutical Preparations; Skin}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85187572294&doi=10.1039\%2fd3cc06130b&partnerID=40&md5=9ee9b5685dd99741d31b962b2e09047c}, abstract = {Herein, we report ethosome (ET) formulations composed of a safe amount of 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine (DMPC)-based ionic liquid with various concentrations of ethanol as a carrier for the transdermal delivery of a high molecular weight drug, insulin. The Insulin-loaded ET vesicles exhibited long-term stability compared to conventional DMPC ETs, showing significantly higher drug encapsulation efficiency and increased skin permeation ability. {\^A}{\copyright} 2024 The Royal Society of Chemistry.}, issn = {13597345}, author = {Nabila, F. H. and Islam, R. and Shimul, I. M. and Moniruzzaman, M. and Wakabayashi, R. and Kamiya, N. and Goto, M.} }