TY  - JOUR
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85159203610&doi=10.25259%2fSNI_118_2023&partnerID=40&md5=53221d1ec3568dd2f52ed0ac6917b6a1
A1  - Idris, Z.
A1  - Yee, A.S.
A1  - Wan Hassan, W.M.N.
A1  - Hassan, M.H.
A1  - Mukmin, L.A.
A1  - Zain, K.A.M.
A1  - Manaf, A.A.
A1  - Balandong, R.P.
A1  - Tang, T.B.
JF  - Surgical Neurology International
VL  - 14
Y1  - 2023///
N1  - cited By 1
N2  - Background: Brain cooling therapy is one of the subjects of interest, and currently, data on direct brain cooling are lacking. Hence, the objective is to investigate the clinical outcomes and discuss the thermodynamics aspect of direct brain cooling on severely injured brain patients. Methods: This pilot study recruited the severely injured brain patients who were then randomized to either a direct brain cooling therapy group using a constant cooling temperature system or a control group. All studied patients must be subjected to an emergency neurosurgical procedure of decompressive craniectomy and were monitored with intracranial pressure, brain oxygenation, and temperature. Further, comparison was made with our historical group of patients who had direct brain cooling therapy through the old technique. Results: The results disclosed the direct brain cooling treated patients through a newer technique obtained a better Extended Glasgow Outcome Score than a control group (P < 001). In addition, there is a significant outcome difference between the combined cooling treated patients (new and old technique) with the control group (P < 0.001). Focal brain oxygenation and temperature are likely factors that correlate with better outcomes. Conclusion: Direct brain cooling is feasible, safe, and affects the clinical outcomes of the severely traumatized brain, and physics of thermodynamics may play a role in its pathophysiology. © 2023 Published by Scientific Scholar on behalf of Surgical Neurology International.
KW  - adult; Article; basal cistern; brain temperature; clinical article; clinical outcome; comparative study; controlled study; decompressive craniectomy; electroencephalogram; female; Glasgow outcome scale; head injury; heart arrhythmia; human; injury severity; intracranial pressure; male; neurosurgeon; pilot study; pneumonia; randomized controlled trial; subarachnoid hemorrhage; subdural hematoma; thermodynamics; thrombosis; wound infection
ID  - scholars19299
TI  - Clinical outcomes and thermodynamics aspect of direct brain cooling in severe head injury
AV  - none
ER  -