TY  - JOUR
N2  - Plant cell culture is seen as an alternative source to whole plants for the production of useful compounds, such as dyes, pharmaceuticals, perfumes and insecticides. Despite intensive research for the last 30 years, only a few products have reached commercial production in bioreactors, and the number is far less than those commercialized for bacterial and animal cells. Several biological challenges including slow cell growth, low productivity, compartmentation, metabolite channelling and poor metabolite secretion have hampered the realization of commercialization of plant cell products. Other engineering and technological problems include cell aggregation, plant cell shear sensitivity, foaming and lack of automation. Several strategies are being explored to improve productivity including medium optimization and cultural conditions, and the understanding of biochemical and signal transduction pathways. In plant cell culture process development, there is a great need to explore a more rational approach through metabolic and genetic engineering by making use of advanced technologies in genomic, transcriptomic, proteomic and metabolomic analyses. These should be integrated with developments in bioprocess and systems engineering.
IS  - 5-6
ID  - scholars19
KW  - Animal cell culture; Bacteria; Bioreactors; Genes; Genetic engineering; Insecticides; Metabolites; Plants (botany); Research; Systems engineering
KW  -  Bioprocess; Cell aggregation; Metabolite channeling; Transduction pathways
KW  -  Plant cell culture
Y1  - 2005///
JF  - Developments in Chemical Engineering and Mineral Processing
A1  - Abdullah, M.A.
A1  - Lajis, N.H.
A1  - Ali, A.M.
A1  - Marziah, M.
A1  - Sinskey, A.J.
A1  - Rha, C.
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-24944560896&doi=10.1002%2fapj.5500130507&partnerID=40&md5=4d8d5f271963e3b04b415df47e691b0c
VL  - 13
AV  - none
N1  - cited By 13
SP  - 573
TI  - Issues in plant cell culture engineering for enhancement of productivity
PB  - Curtin University of Technology
SN  - 09691855
EP  - 587
ER  -