eprintid: 1886
rev_number: 2
eprint_status: archive
userid: 1
dir: disk0/00/00/18/86
datestamp: 2023-11-09 15:50:03
lastmod: 2023-11-09 15:50:03
status_changed: 2023-11-09 15:41:33
type: article
metadata_visibility: show
creators_name: Majumdar, S.
creators_name: Kargupta, K.
creators_name: Ganguly, S.
creators_name: Ray, P.
title: Studies on the performance of the conducting polymer-based molecular release system
ispublished: pub
keywords: Effective diffusivities; Electrical potential; Key objective; Loading time; Molecular release; Therapeutic Application; Voltage cycle, Conducting polymers; Molecules; Organic conductors; Polymer films, Controlled drug delivery
note: cited By 3
abstract: 'Conducting polymeric (CP) membrane based controlled molecular release under applied electrical potential' is an important futuristic application in 'drug delivery'. A validated Poisson-Nernst-Planck based framework has been used in this study for the purpose of performance mapping for such a system. Leaking of the molecules during loading time and retention of molecules at the end of each voltage cycle have been identified here as the major bottlenecks in the use of this system in a sustainable basis. Peak flux of ionic molecules delivered is a key objective to be maximized along with minimum retention and leakage. Results reveal that parameters like time of voltage span, effective diffusivity, polymer film thickness need to be tightly maintained. At the same time, a wide variety of CP-drug combinations can be acceptable. This opens the possibilities of utilizing this system for large range of therapeutic applications for controlled drug delivery. POLYM. ENG. SCI., 2011. © 2011 Society of Plastics Engineers.
date: 2011
official_url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-80052784463&doi=10.1002%2fpen.22022&partnerID=40&md5=eb21bf97d34661045fba22fcaaa86adf
id_number: 10.1002/pen.22022
full_text_status: none
publication: Polymer Engineering and Science
volume: 51
number: 10
pagerange: 2001-2012
refereed: TRUE
issn: 00323888
citation:   Majumdar, S. and Kargupta, K. and Ganguly, S. and Ray, P.  (2011) Studies on the performance of the conducting polymer-based molecular release system.  Polymer Engineering and Science, 51 (10).  pp. 2001-2012.  ISSN 00323888