<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://khub.utp.edu.my/scholars/id/eprint/18666> . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://purl.org/dc/terms/title> "Modification with Conventional Surfactants to Improve a Lipid-Based Ionic-Liquid-Associated Transcutaneous Anticancer Vaccine"^^<http://www.w3.org/2001/XMLSchema#string> . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://purl.org/ontology/bibo/abstract> "Transcutaneous vaccination is one of the successful, affordable, and patient-friendly advanced immunization approaches because of the presence of multiple immune-responsive cell types in the skin. However, in the absence of a preferable facilitator, the skin�s outer layer is a strong impediment to delivering biologically active foreign particles. Lipid-based biocompatible ionic-liquid-mediated nanodrug carriers represent an expedient and distinct strategy to permit transdermal drug delivery; with acceptable surfactants, the performance of drug formulations might be further enhanced. For this purpose, we formulated a lipid-based nanovaccine using a conventional (cationic/anionic/nonionic) surfactant loaded with an antigenic protein and immunomodulator in its core to promote drug delivery by penetrating the skin and boosting drug delivery and immunogenic cell activity. In a follow-up investigation, a freeze�dry emulsification process was used to prepare the nanovaccine, and its transdermal delivery, pharmacokinetic parameters, and ability to activate autoimmune cells in the tumor microenvironment were studied in a tumor-budding C57BL/6N mouse model. These analyses were performed using ELISA, nuclei and HE staining, flow cytometry, and other biological techniques. The immunomodulator-containing nanovaccine significantly (p < 0.001) increased transdermal drug delivery and anticancer immune responses (IgG, IgG1, IgG2, CD8+, CD207+, and CD103+ expression) without causing cellular or biological toxicity. Using a nanovaccination approach, it is possible to create a more targeted and efficient delivery system for cancer antigens, thereby stimulating a stronger immune response compared with conventional aqueous formulations. This might lead to more effective therapeutic and preventative outcomes for patients with cancer. © 2023 by the authors."^^<http://www.w3.org/2001/XMLSchema#string> . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://purl.org/dc/terms/date> "2023" . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://www.w3.org/2002/07/owl#sameAs> <https://doi.org/10.3390/molecules28072969> . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://purl.org/ontology/bibo/volume> "28" . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://purl.org/ontology/bibo/issue> "7" . <https://khub.utp.edu.my/scholars/id/publication/ext-14dea9e846b6ab63cc9a24e89d645c6e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://khub.utp.edu.my/scholars/id/publication/ext-14dea9e846b6ab63cc9a24e89d645c6e> <http://xmlns.com/foaf/0.1/name> "Molecules"^^<http://www.w3.org/2001/XMLSchema#string> . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://purl.org/dc/terms/isPartOf> <https://khub.utp.edu.my/scholars/id/publication/ext-14dea9e846b6ab63cc9a24e89d645c6e> . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/peerReviewed> . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://purl.org/dc/terms/creator> <https://khub.utp.edu.my/scholars/id/person/ext-0fda4abf55fd5a1e3ae09da4e7915750> . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://purl.org/ontology/bibo/authorList> <https://khub.utp.edu.my/scholars/id/eprint/18666#authors> . <https://khub.utp.edu.my/scholars/id/eprint/18666#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://khub.utp.edu.my/scholars/id/person/ext-0fda4abf55fd5a1e3ae09da4e7915750> . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://purl.org/dc/terms/creator> <https://khub.utp.edu.my/scholars/id/person/ext-f335a11dd910fd2178d20ef7fcb61336> . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://purl.org/ontology/bibo/authorList> <https://khub.utp.edu.my/scholars/id/eprint/18666#authors> . <https://khub.utp.edu.my/scholars/id/eprint/18666#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://khub.utp.edu.my/scholars/id/person/ext-f335a11dd910fd2178d20ef7fcb61336> . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://purl.org/dc/terms/creator> <https://khub.utp.edu.my/scholars/id/person/ext-bb2752ea361175c9081b7cd835b4de0b> . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://purl.org/ontology/bibo/authorList> <https://khub.utp.edu.my/scholars/id/eprint/18666#authors> . <https://khub.utp.edu.my/scholars/id/eprint/18666#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://khub.utp.edu.my/scholars/id/person/ext-bb2752ea361175c9081b7cd835b4de0b> . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://purl.org/dc/terms/creator> <https://khub.utp.edu.my/scholars/id/person/ext-f05bede528ffde8cca623a3441a35683> . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://purl.org/ontology/bibo/authorList> <https://khub.utp.edu.my/scholars/id/eprint/18666#authors> . <https://khub.utp.edu.my/scholars/id/eprint/18666#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://khub.utp.edu.my/scholars/id/person/ext-f05bede528ffde8cca623a3441a35683> . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://purl.org/dc/terms/creator> <https://khub.utp.edu.my/scholars/id/person/ext-0655f6b21f99f4758e5a0685418b7130> . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://purl.org/ontology/bibo/authorList> <https://khub.utp.edu.my/scholars/id/eprint/18666#authors> . <https://khub.utp.edu.my/scholars/id/eprint/18666#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://khub.utp.edu.my/scholars/id/person/ext-0655f6b21f99f4758e5a0685418b7130> . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://purl.org/dc/terms/creator> <https://khub.utp.edu.my/scholars/id/person/ext-54268e5f121a861db72c5b41c032e3d4> . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://purl.org/ontology/bibo/authorList> <https://khub.utp.edu.my/scholars/id/eprint/18666#authors> . <https://khub.utp.edu.my/scholars/id/eprint/18666#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://khub.utp.edu.my/scholars/id/person/ext-54268e5f121a861db72c5b41c032e3d4> . <https://khub.utp.edu.my/scholars/id/person/ext-f335a11dd910fd2178d20ef7fcb61336> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://khub.utp.edu.my/scholars/id/person/ext-f335a11dd910fd2178d20ef7fcb61336> <http://xmlns.com/foaf/0.1/givenName> "M.R."^^<http://www.w3.org/2001/XMLSchema#string> . <https://khub.utp.edu.my/scholars/id/person/ext-f335a11dd910fd2178d20ef7fcb61336> <http://xmlns.com/foaf/0.1/familyName> "Islam"^^<http://www.w3.org/2001/XMLSchema#string> . <https://khub.utp.edu.my/scholars/id/person/ext-f335a11dd910fd2178d20ef7fcb61336> <http://xmlns.com/foaf/0.1/name> "M.R. Islam"^^<http://www.w3.org/2001/XMLSchema#string> . <https://khub.utp.edu.my/scholars/id/person/ext-54268e5f121a861db72c5b41c032e3d4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://khub.utp.edu.my/scholars/id/person/ext-54268e5f121a861db72c5b41c032e3d4> <http://xmlns.com/foaf/0.1/givenName> "M."^^<http://www.w3.org/2001/XMLSchema#string> . <https://khub.utp.edu.my/scholars/id/person/ext-54268e5f121a861db72c5b41c032e3d4> <http://xmlns.com/foaf/0.1/familyName> "Goto"^^<http://www.w3.org/2001/XMLSchema#string> . <https://khub.utp.edu.my/scholars/id/person/ext-54268e5f121a861db72c5b41c032e3d4> <http://xmlns.com/foaf/0.1/name> "M. Goto"^^<http://www.w3.org/2001/XMLSchema#string> . <https://khub.utp.edu.my/scholars/id/person/ext-0fda4abf55fd5a1e3ae09da4e7915750> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://khub.utp.edu.my/scholars/id/person/ext-0fda4abf55fd5a1e3ae09da4e7915750> <http://xmlns.com/foaf/0.1/givenName> "S."^^<http://www.w3.org/2001/XMLSchema#string> . <https://khub.utp.edu.my/scholars/id/person/ext-0fda4abf55fd5a1e3ae09da4e7915750> <http://xmlns.com/foaf/0.1/familyName> "Uddin"^^<http://www.w3.org/2001/XMLSchema#string> . <https://khub.utp.edu.my/scholars/id/person/ext-0fda4abf55fd5a1e3ae09da4e7915750> <http://xmlns.com/foaf/0.1/name> "S. Uddin"^^<http://www.w3.org/2001/XMLSchema#string> . <https://khub.utp.edu.my/scholars/id/person/ext-bb2752ea361175c9081b7cd835b4de0b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://khub.utp.edu.my/scholars/id/person/ext-bb2752ea361175c9081b7cd835b4de0b> <http://xmlns.com/foaf/0.1/givenName> "R.M."^^<http://www.w3.org/2001/XMLSchema#string> . <https://khub.utp.edu.my/scholars/id/person/ext-bb2752ea361175c9081b7cd835b4de0b> <http://xmlns.com/foaf/0.1/familyName> "Moshikur"^^<http://www.w3.org/2001/XMLSchema#string> . <https://khub.utp.edu.my/scholars/id/person/ext-bb2752ea361175c9081b7cd835b4de0b> <http://xmlns.com/foaf/0.1/name> "R.M. Moshikur"^^<http://www.w3.org/2001/XMLSchema#string> . <https://khub.utp.edu.my/scholars/id/person/ext-0655f6b21f99f4758e5a0685418b7130> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://khub.utp.edu.my/scholars/id/person/ext-0655f6b21f99f4758e5a0685418b7130> <http://xmlns.com/foaf/0.1/givenName> "M."^^<http://www.w3.org/2001/XMLSchema#string> . <https://khub.utp.edu.my/scholars/id/person/ext-0655f6b21f99f4758e5a0685418b7130> <http://xmlns.com/foaf/0.1/familyName> "Moniruzzaman"^^<http://www.w3.org/2001/XMLSchema#string> . <https://khub.utp.edu.my/scholars/id/person/ext-0655f6b21f99f4758e5a0685418b7130> <http://xmlns.com/foaf/0.1/name> "M. Moniruzzaman"^^<http://www.w3.org/2001/XMLSchema#string> . <https://khub.utp.edu.my/scholars/id/person/ext-f05bede528ffde8cca623a3441a35683> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://khub.utp.edu.my/scholars/id/person/ext-f05bede528ffde8cca623a3441a35683> <http://xmlns.com/foaf/0.1/givenName> "R."^^<http://www.w3.org/2001/XMLSchema#string> . <https://khub.utp.edu.my/scholars/id/person/ext-f05bede528ffde8cca623a3441a35683> <http://xmlns.com/foaf/0.1/familyName> "Wakabayashi"^^<http://www.w3.org/2001/XMLSchema#string> . <https://khub.utp.edu.my/scholars/id/person/ext-f05bede528ffde8cca623a3441a35683> <http://xmlns.com/foaf/0.1/name> "R. Wakabayashi"^^<http://www.w3.org/2001/XMLSchema#string> . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://purl.org/dc/terms/isPartOf> <https://khub.utp.edu.my/scholars/id/repository> . <https://khub.utp.edu.my/scholars/id/eprint/18666> <http://www.w3.org/2000/01/rdf-schema#seeAlso> <https://khub.utp.edu.my/scholars/18666/> . <https://khub.utp.edu.my/scholars/18666/> <http://purl.org/dc/elements/1.1/title> "HTML Summary of #18666 \n\nModification with Conventional Surfactants to Improve a Lipid-Based Ionic-Liquid-Associated Transcutaneous Anticancer Vaccine\n\n" . <https://khub.utp.edu.my/scholars/18666/> <http://purl.org/dc/elements/1.1/format> "text/html" . <https://khub.utp.edu.my/scholars/18666/> <http://xmlns.com/foaf/0.1/primaryTopic> <https://khub.utp.edu.my/scholars/id/eprint/18666> .