%0 Journal Article
%A Lim, S.W.
%A Kansedo, J.
%A Tan, I.S.
%A Tan, Y.H.
%A Nandong, J.
%A Lam, M.K.
%A Ongkudon, C.M.
%D 2023
%F scholars:18435
%J Process Biochemistry
%K Biochemistry; Biodegradable polymers; Conversion efficiency; Elastomers; Fermentation; Life cycle; Oils and fats; Production efficiency, 'current; Bio-plastics; Biodegradable plastics; Fermentation strategy; Kinetic study; Lipid-rich oil; Oil based; Polyhydroxyalkanoates; Production efficiency; Valorisation, Substrates
%P 715-733
%R 10.1016/j.procbio.2023.05.013
%T Microbial valorization of oil-based substrates for polyhydroxyalkanoates (PHA) production � Current strategies, status, and perspectives
%U https://khub.utp.edu.my/scholars/18435/
%V 130
%X With the rising interest in developing polyhydroxyalkanoate (PHA) bioplastics as an auspicious substitute for conventional plastics, the exploitation of low-cost oil substrates for PHA biosynthesis has become popular recently. In view of the paucity of feasibility studies on lipid-based PHA production, this paper aims to provide an overview of the PHA production from diverse lipid-rich sources, covering the PHA production efficiencies using different plausible fermentation strategies and the key influencing factors for oil-based PHA production. Considering the high conversion efficiency (97.5 of the theoretical PHA yield), direct fermentation of oil has shown great promise for PHA industrialization. Plant oils which could achieve a high PHA yield (0.25�0.77 g/g) are better carbon sources than waste cooking oil (0.15�0.28 g/g). In addition to providing information on the potential enhancement tools (i.e., mixed cultures, metabolic engineering, and kinetic studies) for lipid-based PHA production, this paper also reviews the techno-economic and life cycle assessment of PHA production in comparison to the conventional plastics. Besides, technical challenges and future perspectives for the commercialization of oil-based PHA production have been discussed (specifically targeting on the concerns of inconsistent production efficiency, complex recovery process, and high production cost), offering further insights towards developing a sustainable circular economy. © 2023
%Z cited By 5