relation: https://khub.utp.edu.my/scholars/18435/
title: Microbial valorization of oil-based substrates for polyhydroxyalkanoates (PHA) production � Current strategies, status, and perspectives
creator: Lim, S.W.
creator: Kansedo, J.
creator: Tan, I.S.
creator: Tan, Y.H.
creator: Nandong, J.
creator: Lam, M.K.
creator: Ongkudon, C.M.
description: With the rising interest in developing polyhydroxyalkanoate (PHA) bioplastics as an auspicious substitute for conventional plastics, the exploitation of low-cost oil substrates for PHA biosynthesis has become popular recently. In view of the paucity of feasibility studies on lipid-based PHA production, this paper aims to provide an overview of the PHA production from diverse lipid-rich sources, covering the PHA production efficiencies using different plausible fermentation strategies and the key influencing factors for oil-based PHA production. Considering the high conversion efficiency (97.5 of the theoretical PHA yield), direct fermentation of oil has shown great promise for PHA industrialization. Plant oils which could achieve a high PHA yield (0.25�0.77 g/g) are better carbon sources than waste cooking oil (0.15�0.28 g/g). In addition to providing information on the potential enhancement tools (i.e., mixed cultures, metabolic engineering, and kinetic studies) for lipid-based PHA production, this paper also reviews the techno-economic and life cycle assessment of PHA production in comparison to the conventional plastics. Besides, technical challenges and future perspectives for the commercialization of oil-based PHA production have been discussed (specifically targeting on the concerns of inconsistent production efficiency, complex recovery process, and high production cost), offering further insights towards developing a sustainable circular economy. © 2023
date: 2023
type: Article
type: PeerReviewed
identifier:   Lim, S.W. and Kansedo, J. and Tan, I.S. and Tan, Y.H. and Nandong, J. and Lam, M.K. and Ongkudon, C.M.  (2023) Microbial valorization of oil-based substrates for polyhydroxyalkanoates (PHA) production � Current strategies, status, and perspectives.  Process Biochemistry, 130.  pp. 715-733.      
relation: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85160673512&doi=10.1016%2fj.procbio.2023.05.013&partnerID=40&md5=b03838f5a6a9e2228038201e975cac34
relation: 10.1016/j.procbio.2023.05.013
identifier: 10.1016/j.procbio.2023.05.013