@article{scholars18435,
           title = {Microbial valorization of oil-based substrates for polyhydroxyalkanoates (PHA) production {\^a}?? Current strategies, status, and perspectives},
         journal = {Process Biochemistry},
           pages = {715--733},
          volume = {130},
            note = {cited By 5},
             doi = {10.1016/j.procbio.2023.05.013},
            year = {2023},
             url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85160673512&doi=10.1016\%2fj.procbio.2023.05.013&partnerID=40&md5=b03838f5a6a9e2228038201e975cac34},
        keywords = {Biochemistry; Biodegradable polymers; Conversion efficiency; Elastomers; Fermentation; Life cycle; Oils and fats; Production efficiency, 'current; Bio-plastics; Biodegradable plastics; Fermentation strategy; Kinetic study; Lipid-rich oil; Oil based; Polyhydroxyalkanoates; Production efficiency; Valorisation, Substrates},
        abstract = {With the rising interest in developing polyhydroxyalkanoate (PHA) bioplastics as an auspicious substitute for conventional plastics, the exploitation of low-cost oil substrates for PHA biosynthesis has become popular recently. In view of the paucity of feasibility studies on lipid-based PHA production, this paper aims to provide an overview of the PHA production from diverse lipid-rich sources, covering the PHA production efficiencies using different plausible fermentation strategies and the key influencing factors for oil-based PHA production. Considering the high conversion efficiency (97.5 of the theoretical PHA yield), direct fermentation of oil has shown great promise for PHA industrialization. Plant oils which could achieve a high PHA yield (0.25{\^a}??0.77 g/g) are better carbon sources than waste cooking oil (0.15{\^a}??0.28 g/g). In addition to providing information on the potential enhancement tools (i.e., mixed cultures, metabolic engineering, and kinetic studies) for lipid-based PHA production, this paper also reviews the techno-economic and life cycle assessment of PHA production in comparison to the conventional plastics. Besides, technical challenges and future perspectives for the commercialization of oil-based PHA production have been discussed (specifically targeting on the concerns of inconsistent production efficiency, complex recovery process, and high production cost), offering further insights towards developing a sustainable circular economy. {\^A}{\copyright} 2023},
          author = {Lim, S. W. and Kansedo, J. and Tan, I. S. and Tan, Y. H. and Nandong, J. and Lam, M. K. and Ongkudon, C. M.}
}