TY  - JOUR
AV  - none
N1  - cited By 9
N2  - Benefits achieved by the biodegradable magnesium (Mg) and zinc (Zn) implants could be suppressed due to the invasion of infectious microbial, common bacteria, and fungi. Postoperative medications and the antibacterial properties of pure Mg and Zn are insufficient against biofilm and antibiotic-resistant bacteria, bringing osteomyelitis, necrosis, and even death. This study evaluates the antibacterial performance of biodegradable Mg and Zn alloys of different reinforcements, including silver (Ag), copper (Cu), lithium (Li), and gallium (Ga). Copper ions (Cu2+) can eradicate biofilms and antibiotic-resistant bacteria by extracting electrons from the cellular structure. Silver ion (Ag+) kills bacteria by creating bonds with the thiol group. Gallium ion (Ga3+) inhibits ferric ion (Fe3+) absorption, leading to nutrient deficiency and bacterial death. Nanoparticles and reactive oxygen species (ROS) can penetrate bacteria cell walls directly, develop bonds with receptors, and damage nucleotides. Antibacterial action depends on the alkali nature of metal ions and their degradation rate, which often causes cytotoxicity in living cells. Therefore, this review emphasizes the insight into degradation rate, antibacterial mechanism, and their consequent cytotoxicity and observes the correlation between antibacterial performance and oxidation number of metal ions. © 2023
IS  - 9
KW  - Antibiotics; Bacteria; Biofilms; Cell death; Copper; Degradation; Gallium; Magnesium alloys; Metal ions; Oxygen; Reinforcement; Zinc alloys
KW  -  Antibacterial mechanisms; Antibacterial performance; Antibacterial properties; Antibiotic-resistant bacteria; Biodegradable magnesiums; Biodegradable material; Biomedical implants; Degradation rate; Metals ions; Reactive oxygen species
KW  -  Cytotoxicity
SP  - 3038
TI  - Antibacterial mechanism with consequent cytotoxicity of different reinforcements in biodegradable magnesium and zinc alloys: A review
ID  - scholars18251
Y1  - 2023///
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85171687024&doi=10.1016%2fj.jma.2023.08.018&partnerID=40&md5=2b557988b6d55507cb71bc461564760d
JF  - Journal of Magnesium and Alloys
A1  - Shahed, C.A.
A1  - Ahmad, F.
A1  - Günister, E.
A1  - Foudzi, F.M.
A1  - Ali, S.
A1  - Malik, K.
A1  - Harun, W.S.W.
VL  - 11
EP  - 3058
ER  -