%D 2023
%R 10.1177/10870547231180111
%N 13
%O cited By 4
%L scholars18110
%J Journal of Attention Disorders
%X Objective: Functional near-infrared spectroscopy (fNIRS) provides direct and quantitative assessment of cortical hemodynamic response. It has been used to identify neurophysiological alterations in medication-naïve adults with attention-deficit/hyperactivity disorder (ADHD). Hence, this study aimed to distinguish both medication-naïve and medicated adults with ADHD from healthy controls (HC). Method: 75 HCs, 75 medication-naïve, and 45 medicated patients took part in this study. fNIRS signals during a verbal fluency task (VFT) were acquired using a 52-channel system and relative oxy-hemoglobin changes in the prefrontal cortex were quantified. Results: Prefrontal cortex hemodynamic response was lower in patients than HCs (p � �.001). Medication-naïve and medicated patients did not differ in hemodynamic response or symptom severity (p >.05). fNIRS measurements were not associated with any clinical variables (p >.05). 75.8 patients and 76 HCs were correctly classified using hemodynamic response. Conclusion: fNIRS may be a potential diagnostic tool for adult ADHD. These findings need to be replicated in larger validation studies. © ©The Author(s) 2023.
%K adult; attention deficit hyperactivity disorder; hemodynamics; human; near infrared spectroscopy; physiology; prefrontal cortex; procedures, Adult; Attention Deficit Disorder with Hyperactivity; Hemodynamics; Humans; Prefrontal Cortex; Spectroscopy, Near-Infrared
%P 1448-1459
%T Functional Near-Infrared Spectroscopy of English-Speaking Adults With Attention-Deficit/Hyperactivity Disorder During a Verbal Fluency Task
%V 27
%A S.F. Husain
%A S.K. Chiang
%A A.A. Vasu
%A C.P. Goh
%A R.S. McIntyre
%A T.B. Tang
%A B.X. Tran
%A T.H.T. Dang
%A T.T. Nguyen
%A R.C. Ho
%A C.S. Ho