TY  - JOUR
N2  - Objective: Functional near-infrared spectroscopy (fNIRS) provides direct and quantitative assessment of cortical hemodynamic response. It has been used to identify neurophysiological alterations in medication-naïve adults with attention-deficit/hyperactivity disorder (ADHD). Hence, this study aimed to distinguish both medication-naïve and medicated adults with ADHD from healthy controls (HC). Method: 75 HCs, 75 medication-naïve, and 45 medicated patients took part in this study. fNIRS signals during a verbal fluency task (VFT) were acquired using a 52-channel system and relative oxy-hemoglobin changes in the prefrontal cortex were quantified. Results: Prefrontal cortex hemodynamic response was lower in patients than HCs (p � �.001). Medication-naïve and medicated patients did not differ in hemodynamic response or symptom severity (p >.05). fNIRS measurements were not associated with any clinical variables (p >.05). 75.8 patients and 76 HCs were correctly classified using hemodynamic response. Conclusion: fNIRS may be a potential diagnostic tool for adult ADHD. These findings need to be replicated in larger validation studies. © ©The Author(s) 2023.
N1  - cited By 4
IS  - 13
KW  - adult; attention deficit hyperactivity disorder; hemodynamics; human; near infrared spectroscopy; physiology; prefrontal cortex; procedures
KW  -  Adult; Attention Deficit Disorder with Hyperactivity; Hemodynamics; Humans; Prefrontal Cortex; Spectroscopy
KW  -  Near-Infrared
TI  - Functional Near-Infrared Spectroscopy of English-Speaking Adults With Attention-Deficit/Hyperactivity Disorder During a Verbal Fluency Task
ID  - scholars18110
SP  - 1448
AV  - none
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85162761543&doi=10.1177%2f10870547231180111&partnerID=40&md5=f3f7796394d3ed9eb9dedb8dad043b8b
JF  - Journal of Attention Disorders
A1  - Husain, S.F.
A1  - Chiang, S.K.
A1  - Vasu, A.A.
A1  - Goh, C.P.
A1  - McIntyre, R.S.
A1  - Tang, T.B.
A1  - Tran, B.X.
A1  - Dang, T.H.T.
A1  - Nguyen, T.T.
A1  - Ho, R.C.
A1  - Ho, C.S.
VL  - 27
EP  - 1459
Y1  - 2023///
ER  -