%0 Journal Article
%A Husain, S.F.
%A Chiang, S.K.
%A Vasu, A.A.
%A Goh, C.P.
%A McIntyre, R.S.
%A Tang, T.B.
%A Tran, B.X.
%A Dang, T.H.T.
%A Nguyen, T.T.
%A Ho, R.C.
%A Ho, C.S.
%D 2023
%F scholars:18110
%J Journal of Attention Disorders
%K adult; attention deficit hyperactivity disorder; hemodynamics; human; near infrared spectroscopy; physiology; prefrontal cortex; procedures, Adult; Attention Deficit Disorder with Hyperactivity; Hemodynamics; Humans; Prefrontal Cortex; Spectroscopy, Near-Infrared
%N 13
%P 1448-1459
%R 10.1177/10870547231180111
%T Functional Near-Infrared Spectroscopy of English-Speaking Adults With Attention-Deficit/Hyperactivity Disorder During a Verbal Fluency Task
%U https://khub.utp.edu.my/scholars/18110/
%V 27
%X Objective: Functional near-infrared spectroscopy (fNIRS) provides direct and quantitative assessment of cortical hemodynamic response. It has been used to identify neurophysiological alterations in medication-naïve adults with attention-deficit/hyperactivity disorder (ADHD). Hence, this study aimed to distinguish both medication-naïve and medicated adults with ADHD from healthy controls (HC). Method: 75 HCs, 75 medication-naïve, and 45 medicated patients took part in this study. fNIRS signals during a verbal fluency task (VFT) were acquired using a 52-channel system and relative oxy-hemoglobin changes in the prefrontal cortex were quantified. Results: Prefrontal cortex hemodynamic response was lower in patients than HCs (p � �.001). Medication-naïve and medicated patients did not differ in hemodynamic response or symptom severity (p >.05). fNIRS measurements were not associated with any clinical variables (p >.05). 75.8 patients and 76 HCs were correctly classified using hemodynamic response. Conclusion: fNIRS may be a potential diagnostic tool for adult ADHD. These findings need to be replicated in larger validation studies. © ©The Author(s) 2023.
%Z cited By 4