TY  - JOUR
VL  - 195
JF  - Microchemical Journal
A1  - Vasudevan, M.
A1  - Remesh, S.
A1  - Perumal, V.
A1  - Raja, P.B.
A1  - Ibrahim, M.N.M.
A1  - Gopinath, S.C.B.
A1  - Lee, H.-L.
A1  - Karuppanan, S.
A1  - Ovinis, M.
A1  - Arumugam, N.
A1  - Kumar, R.S.
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85172194275&doi=10.1016%2fj.microc.2023.109405&partnerID=40&md5=ccc32a0f5b697b8ac27c9a8045f69d24
Y1  - 2023///
ID  - scholars18018
TI  - Lignin derived nanoparticle intercalation on nitrogen-doped graphene quantum dots for electrochemical sensing of cardiac biomarker
N1  - cited By 0
N2  - Lignin-scribed graphene (LSG) conjugated with nitrogen-doped graphene quantum dots (N-GQDs) and lignin-derived silver nanoparticles (Ag NPs) was developed through a hydrothermal process for the electrochemical sensing of Troponin I, a cardiac biomarker for Acute Myocardial Infarction (AMI). A nanocomposite with optimal conduction mechanism was developed by varying the N-GQDs doped amount intercalated on the surface of LSG. The nanocomposite was characterised by morphological, physical, and structural examinations. The Ag NPs and N-GQDs were found uniformly distributed on the LSG surface, with selective capture of the biotinylated aptamer probe on the bio-electrode indicative of the specific interaction with Troponin I, resulting in an increment in the charge transfer resistance following hybridisation analysis. The detection limit, as determined through impedance spectroscopy, was 1 fM or 30 fg/mL, with high levels of linearity, selectivity, repeatability, and stability of the sensor. This nanocomposite opens a new avenue for array-based medical diagnostics. © 2023
AV  - none
ER  -