@article{scholars18018,
             doi = {10.1016/j.microc.2023.109405},
            year = {2023},
          volume = {195},
            note = {cited By 0},
           title = {Lignin derived nanoparticle intercalation on nitrogen-doped graphene quantum dots for electrochemical sensing of cardiac biomarker},
         journal = {Microchemical Journal},
          author = {Vasudevan, M. and Remesh, S. and Perumal, V. and Raja, P. B. and Ibrahim, M. N. M. and Gopinath, S. C. B. and Lee, H.-L. and Karuppanan, S. and Ovinis, M. and Arumugam, N. and Kumar, R. S.},
             url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85172194275&doi=10.1016\%2fj.microc.2023.109405&partnerID=40&md5=ccc32a0f5b697b8ac27c9a8045f69d24},
        abstract = {Lignin-scribed graphene (LSG) conjugated with nitrogen-doped graphene quantum dots (N-GQDs) and lignin-derived silver nanoparticles (Ag NPs) was developed through a hydrothermal process for the electrochemical sensing of Troponin I, a cardiac biomarker for Acute Myocardial Infarction (AMI). A nanocomposite with optimal conduction mechanism was developed by varying the N-GQDs doped amount intercalated on the surface of LSG. The nanocomposite was characterised by morphological, physical, and structural examinations. The Ag NPs and N-GQDs were found uniformly distributed on the LSG surface, with selective capture of the biotinylated aptamer probe on the bio-electrode indicative of the specific interaction with Troponin I, resulting in an increment in the charge transfer resistance following hybridisation analysis. The detection limit, as determined through impedance spectroscopy, was 1 fM or 30 fg/mL, with high levels of linearity, selectivity, repeatability, and stability of the sensor. This nanocomposite opens a new avenue for array-based medical diagnostics. {\^A}{\copyright} 2023}
}