%P 577-592
%T Gold-Nanohybrid Biosensors for Analyzing Blood Circulating Clinical Biomacromolecules: Current Trend toward Future Remote Digital Monitoring
%I Taylor and Francis Ltd.
%A I. Letchumanan
%A S.C.B. Gopinath
%A M.K. Md Arshad
%A M.S. Mohamed Saheed
%A V. Perumal
%A C.H. Voon
%A U. Hashim
%V 52
%D 2022
%N 3
%R 10.1080/10408347.2020.1812373
%O cited By 6
%J Critical Reviews in Analytical Chemistry
%L scholars17930
%K Biocompatibility; Biomarkers; Biosensors; Blood; Gold; Nanocomposites; Plasmons; Surface plasmon resonance, Bio-sensor platforms; Diagnostic methods; Digital monitoring; Disease biomarker; Electron transfer; Gold nanocomposites; Localized surface plasmon resonance; Surface-to-volume ratio, Diagnosis, biomarker; blood; digitization; gold; molecular analysis; monitoring; nanocomposite; nanoparticle; sensor; trend analysis, gold; metal nanoparticle; nanocomposite, chemistry; genetic procedures; human; procedures; surface plasmon resonance, Biosensing Techniques; Gold; Humans; Metal Nanoparticles; Nanocomposites; Surface Plasmon Resonance
%X Mortality level is worsening the situation worldwide thru blood diseases and greatly jeopardizes the human health with poor diagnostics. Due to the lack of successful generation of early diagnosis, the survival rate is currently lower. To overcome the present hurdle, new diagnostic methods have been choreographed for blood disease biomarkers analyses with the conjunction of ultra-small ideal gold nanohybrids. Gold-hybrids hold varieties of unique features, such as high biocompatibility, increased surface-to-volume ratio, less-toxicity, ease in electron transfer and have a greater localized surface plasmon resonance. Gold-nanocomposites can be physically hybrid on the sensor surface and functionalize with the biomolecules using appropriate chemical conjugations. Revolutionizing biosensor platform can be prominently linked for the nanocomposite applications in the current research on medical diagnosis. This review encloses the new developments in diagnosing blood biomarkers by utilizing the gold-nanohybrids. Further, the current state-of-the-art and the future envision with digital monitoring for facile telediagnosis were narrated. © 2020 Taylor & Francis Group, LLC.