TY  - JOUR
N2  - Mortality level is worsening the situation worldwide thru blood diseases and greatly jeopardizes the human health with poor diagnostics. Due to the lack of successful generation of early diagnosis, the survival rate is currently lower. To overcome the present hurdle, new diagnostic methods have been choreographed for blood disease biomarkers analyses with the conjunction of ultra-small ideal gold nanohybrids. Gold-hybrids hold varieties of unique features, such as high biocompatibility, increased surface-to-volume ratio, less-toxicity, ease in electron transfer and have a greater localized surface plasmon resonance. Gold-nanocomposites can be physically hybrid on the sensor surface and functionalize with the biomolecules using appropriate chemical conjugations. Revolutionizing biosensor platform can be prominently linked for the nanocomposite applications in the current research on medical diagnosis. This review encloses the new developments in diagnosing blood biomarkers by utilizing the gold-nanohybrids. Further, the current state-of-the-art and the future envision with digital monitoring for facile telediagnosis were narrated. © 2020 Taylor & Francis Group, LLC.
IS  - 3
KW  - Biocompatibility; Biomarkers; Biosensors; Blood; Gold; Nanocomposites; Plasmons; Surface plasmon resonance
KW  -  Bio-sensor platforms; Diagnostic methods; Digital monitoring; Disease biomarker; Electron transfer; Gold nanocomposites; Localized surface plasmon resonance; Surface-to-volume ratio
KW  -  Diagnosis
KW  -  biomarker; blood; digitization; gold; molecular analysis; monitoring; nanocomposite; nanoparticle; sensor; trend analysis
KW  -  gold; metal nanoparticle; nanocomposite
KW  -  chemistry; genetic procedures; human; procedures; surface plasmon resonance
KW  -  Biosensing Techniques; Gold; Humans; Metal Nanoparticles; Nanocomposites; Surface Plasmon Resonance
ID  - scholars17930
Y1  - 2022///
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090443106&doi=10.1080%2f10408347.2020.1812373&partnerID=40&md5=573ebab0f5078b89de49fdb9bc377c63
A1  - Letchumanan, I.
A1  - Gopinath, S.C.B.
A1  - Md Arshad, M.K.
A1  - Mohamed Saheed, M.S.
A1  - Perumal, V.
A1  - Voon, C.H.
A1  - Hashim, U.
JF  - Critical Reviews in Analytical Chemistry
VL  - 52
AV  - none
N1  - cited By 6
TI  - Gold-Nanohybrid Biosensors for Analyzing Blood Circulating Clinical Biomacromolecules: Current Trend toward Future Remote Digital Monitoring
SP  - 577
SN  - 10408347
PB  - Taylor and Francis Ltd.
EP  - 592
ER  -