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primary topic: Thyroglobulin determination on silaneâ��antibody functionalized interdigitated dielectrode surface to diagnose thyroid tumor

Thyroglobulin determination on silaneâ��antibody functionalized interdigitated dielectrode surface to diagnose thyroid tumor
type: AcademicArticle
type: Article
abstract: Thyroid cancer appears in endocrine glands and specific to thyroid glands has been reported widely. This work was targeted to identify and quantify thyroglobulin by using antithyroglobulin antibody complexed silane surface on interdigitated electrode (IDE) sensing surface. (3-Aminopropyl)triethoxysilane linker was used to make silane-coupling with antibody and attached on the hydroxylated IDE. This electroanalytical IDE revealed the dose-dependent responses with thyroglobulin concentrations. By getting increments with the thyroglobulin concentrations, the current responses were enhanced concomitantly and the thyroglobulin detection limit was noted as 1 pM on the linear curve y =Â 0.1311x +Â 0.5386; RÂ² =Â 0.9707 with the sensitivity at lower picomolar range. Moreover, the control experiments with thyroid peroxidase and nonimmune antibody cannot yield any response of current, confirming the specific detection of thyroglobulin. This research set-up is useful to determine and quantify the thyroglobulin and diagnose thyroid cancer. © 2021 International Union of Biochemistry and Molecular Biology, Inc.
date: 2022
volume: 69
issue: 1
is part of: Biotechnology and Applied Biochemistry
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository

John Wiley and Sons Inc
type: Organization

Biotechnology and Applied Biochemistry
type: Collection
issn: 08854513

S.C.B. Gopinath
type: Person
given name: S.C.B.
family name: Gopinath

X. Wang
type: Person
given name: X.
family name: Wang

M.S.M. Saheed
type: Person
given name: M.S.M.
family name: Saheed

Y. Wang
type: Person
given name: Y.
family name: Wang

X. Sun
type: Person
given name: X.
family name: Sun

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primary topic: Thyroglobulin determination on silaneâ��antibody functionalized interdigitated dielectrode surface to diagnose thyroid tumor