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primary topic: Fiber-specific white matter analysis reflects upper motor neuron impairment in amyotrophic lateral sclerosis

Fiber-specific white matter analysis reflects upper motor neuron impairment in amyotrophic lateral sclerosis
type: AcademicArticle
type: Article
abstract: Background and purpose: To clarify the relationship between fiber-specific white matter changes in amyotrophic lateral sclerosis (ALS) and clinical signs of upper motor neuron (UMN) involvement, we performed a fixel-based analysis (FBA), a novel framework for diffusion-weighted imaging analysis. Methods: We enrolled 96 participants, including 48 nonfamilial ALS patients and 48 age- and sex-matched healthy controls (HCs), in this study and conducted whole-brain FBA and voxel-based morphometry analysis. We compared the fiber density (FD), fiber morphology (fiber cross-section FC), and a combined index of FD and FC (FDC) between the ALS and HC groups. We performed a tract-of-interest analysis to extract FD values across the significant regions in the whole-brain analysis. Then, we evaluated the associations between FD values and clinical variables. Results: The bilateral corticospinal tracts (CSTs) and the corpus callosum (CC) showed reduced FD and FDC in ALS patients compared with HCs (p <Â 0.05, familywise error-corrected), and the comparison of FCs revealed no region that was significantly different from another. Voxel-based morphometry showed cortical volume reduction in the regions, including the primary motor area. Clinical scores showed correlations with FD values in the CSTs (UMN score: rho =Â â��0.530, p <Â 0.001; central motor conduction time CMCT in the upper limb: rho =Â â��0.474, p =Â 0.008; disease duration: rho =Â â��0.383, p =Â 0.007; ALS Functional Rating Scale-Revised: rho =Â 0.340, p =Â 0.018). In addition, patients whose CMCT was not calculated due to unevoked waves also showed FD reduction in the CSTs. Conclusions: Our findings suggest that FD values in the CST estimated via FBA can be potentially used in evaluating UMN impairments. © 2021 European Academy of Neurology
date: 2022
volume: 29
issue: 2
is part of: European Journal of Neurology
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository

John Wiley and Sons Inc
type: Organization

European Journal of Neurology
type: Collection
issn: 13515101

G. Sobue
type: Person
given name: G.
family name: Sobue

M. Katsuno
type: Person
given name: M.
family name: Katsuno

T. Kato
type: Person
given name: T.
family name: Kato

T. Nakamura
type: Person
given name: T.
family name: Nakamura

H. Watanabe
type: Person
given name: H.
family name: Watanabe

R. Ohdake
type: Person
given name: R.
family name: Ohdake

N. Atsuta
type: Person
given name: N.
family name: Atsuta

K. Hara
type: Person
given name: K.
family name: Hara

K. Imai
type: Person
given name: K.
family name: Imai

S.W. Choy
type: Person
given name: S.W.
family name: Choy

A. Ogura
type: Person
given name: A.
family name: Ogura

K. Kawabata
type: Person
given name: K.
family name: Kawabata

R. Nakamura
type: Person
given name: R.
family name: Nakamura

E. Bagarinao
type: Person
given name: E.
family name: Bagarinao

M. Masuda
type: Person
given name: M.
family name: Masuda

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primary topic: Fiber-specific white matter analysis reflects upper motor neuron impairment in amyotrophic lateral sclerosis