%0 Journal Article
%@ 13515101
%A Ogura, A.
%A Kawabata, K.
%A Watanabe, H.
%A Choy, S.W.
%A Bagarinao, E.
%A Kato, T.
%A Imai, K.
%A Masuda, M.
%A Ohdake, R.
%A Hara, K.
%A Nakamura, R.
%A Atsuta, N.
%A Nakamura, T.
%A Katsuno, M.
%A Sobue, G.
%D 2022
%F scholars:17154
%I John Wiley and Sons Inc
%J European Journal of Neurology
%K adult; amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised; Article; clinical article; clinical feature; controlled study; corpus callosum; cross-sectional study; diffusion weighted imaging; disease duration; feature extraction; female; fixel based analysis; human; human cell; image analysis; male; middle aged; motor neuron disease; neuroimaging; primary motor cortex; pyramidal tract; transcranial magnetic stimulation; voxel based morphometry; white matter; amyotrophic lateral sclerosis; diagnostic imaging; diffusion tensor imaging; motoneuron, Amyotrophic Lateral Sclerosis; Diffusion Tensor Imaging; Humans; Motor Neurons; Pyramidal Tracts; White Matter
%N 2
%P 432-440
%R 10.1111/ene.15136
%T Fiber-specific white matter analysis reflects upper motor neuron impairment in amyotrophic lateral sclerosis
%U https://khub.utp.edu.my/scholars/17154/
%V 29
%X Background and purpose: To clarify the relationship between fiber-specific white matter changes in amyotrophic lateral sclerosis (ALS) and clinical signs of upper motor neuron (UMN) involvement, we performed a fixel-based analysis (FBA), a novel framework for diffusion-weighted imaging analysis. Methods: We enrolled 96 participants, including 48 nonfamilial ALS patients and 48 age- and sex-matched healthy controls (HCs), in this study and conducted whole-brain FBA and voxel-based morphometry analysis. We compared the fiber density (FD), fiber morphology (fiber cross-section FC), and a combined index of FD and FC (FDC) between the ALS and HC groups. We performed a tract-of-interest analysis to extract FD values across the significant regions in the whole-brain analysis. Then, we evaluated the associations between FD values and clinical variables. Results: The bilateral corticospinal tracts (CSTs) and the corpus callosum (CC) showed reduced FD and FDC in ALS patients compared with HCs (p < 0.05, familywise error-corrected), and the comparison of FCs revealed no region that was significantly different from another. Voxel-based morphometry showed cortical volume reduction in the regions, including the primary motor area. Clinical scores showed correlations with FD values in the CSTs (UMN score: rho = �0.530, p < 0.001; central motor conduction time CMCT in the upper limb: rho = �0.474, p = 0.008; disease duration: rho = �0.383, p = 0.007; ALS Functional Rating Scale-Revised: rho = 0.340, p = 0.018). In addition, patients whose CMCT was not calculated due to unevoked waves also showed FD reduction in the CSTs. Conclusions: Our findings suggest that FD values in the CST estimated via FBA can be potentially used in evaluating UMN impairments. © 2021 European Academy of Neurology
%Z cited By 6