relation: https://khub.utp.edu.my/scholars/17154/
title: Fiber-specific white matter analysis reflects upper motor neuron impairment in amyotrophic lateral sclerosis
creator: Ogura, A.
creator: Kawabata, K.
creator: Watanabe, H.
creator: Choy, S.W.
creator: Bagarinao, E.
creator: Kato, T.
creator: Imai, K.
creator: Masuda, M.
creator: Ohdake, R.
creator: Hara, K.
creator: Nakamura, R.
creator: Atsuta, N.
creator: Nakamura, T.
creator: Katsuno, M.
creator: Sobue, G.
description: Background and purpose: To clarify the relationship between fiber-specific white matter changes in amyotrophic lateral sclerosis (ALS) and clinical signs of upper motor neuron (UMN) involvement, we performed a fixel-based analysis (FBA), a novel framework for diffusion-weighted imaging analysis. Methods: We enrolled 96 participants, including 48 nonfamilial ALS patients and 48 age- and sex-matched healthy controls (HCs), in this study and conducted whole-brain FBA and voxel-based morphometry analysis. We compared the fiber density (FD), fiber morphology (fiber cross-section FC), and a combined index of FD and FC (FDC) between the ALS and HC groups. We performed a tract-of-interest analysis to extract FD values across the significant regions in the whole-brain analysis. Then, we evaluated the associations between FD values and clinical variables. Results: The bilateral corticospinal tracts (CSTs) and the corpus callosum (CC) showed reduced FD and FDC in ALS patients compared with HCs (p < 0.05, familywise error-corrected), and the comparison of FCs revealed no region that was significantly different from another. Voxel-based morphometry showed cortical volume reduction in the regions, including the primary motor area. Clinical scores showed correlations with FD values in the CSTs (UMN score: rho = �0.530, p < 0.001; central motor conduction time CMCT in the upper limb: rho = �0.474, p = 0.008; disease duration: rho = �0.383, p = 0.007; ALS Functional Rating Scale-Revised: rho = 0.340, p = 0.018). In addition, patients whose CMCT was not calculated due to unevoked waves also showed FD reduction in the CSTs. Conclusions: Our findings suggest that FD values in the CST estimated via FBA can be potentially used in evaluating UMN impairments. © 2021 European Academy of Neurology
publisher: John Wiley and Sons Inc
date: 2022
type: Article
type: PeerReviewed
identifier:   Ogura, A. and Kawabata, K. and Watanabe, H. and Choy, S.W. and Bagarinao, E. and Kato, T. and Imai, K. and Masuda, M. and Ohdake, R. and Hara, K. and Nakamura, R. and Atsuta, N. and Nakamura, T. and Katsuno, M. and Sobue, G.  (2022) Fiber-specific white matter analysis reflects upper motor neuron impairment in amyotrophic lateral sclerosis.  European Journal of Neurology, 29 (2).  pp. 432-440.  ISSN 13515101     
relation: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118302510&doi=10.1111%2fene.15136&partnerID=40&md5=6d92ebf69e74b9d90984cb2a556526e4
relation: 10.1111/ene.15136
identifier: 10.1111/ene.15136