TY  - JOUR
N2  - Realising the need to devise a simple, sensitive, and reliable detection method, this study investigated the development of a dual-stacking transient isotachophoresis (t-ITP) and sweeping in micellar electrokinetic chromatography with diode array detector (t-ITP/sweeping-MEKC-DAD) for the determination of selected non-steroidal anti-inflammatory drugs (NSAIDs); ketoprofen, diclofenac and naproxen from aqueous matrices. Prior to the system setup, various parameters were optimised to assess the potential use of the t-ITP paired with the sweeping stacking technique in micellar background electrolyte for dual preconcentration and separation of trace amounts of NSAIDs. Once the optimum conditions have been established, the method performance was validated and applied to 17 environmental water samples. Based on the results, the combined t-ITP and sweeping approach significantly improved the stacking and separation sensitivity. A large volume of samples could also be introduced and subsequently separated by MEKC with greater focusing effects due to the sweeping. Under optimised conditions, the developed method exhibited excellent linearity at a high range (0.1â??500 ng/mL, r2 â?¥ 0.998), low limits of detection (LODs) of 0.01â??0.07 ng/mL, and a remarkable relative recovery (RR) of 99.6â??101.9 with a relative standard deviation (RSD) of 1.4â??8.6 (n = 9). Ultimately, the sensitivity enhancement factors improved up to 666-fold using the optimised method. Therefore, the proposed method presents a simplified yet effective and suitable for the determination of NSAIDs from aqueous matrices. © 2022
N1  - cited By 4
KW  - Electrodynamics; Electrolytes; Liquid chromatography
KW  -  Aqueous matrix; Environmental sample; Environmental water samples; Micellar electrokinetic chromatography; Non-steroidal anti-inflammatory drugs; Sensitive detection; Simple++; Stackings; Sweeping; Transient isotachophoresis
KW  -  Separation
KW  -  ammonium acetate; diclofenac; dodecyl sulfate sodium; electrolyte; hydrochloric acid; ketoprofen; methanol; naproxen; nonsteroid antiinflammatory agent; octanol; sodium chloride; sodium hydroxide; water; nonsteroid antiinflammatory agent; water
KW  -  Article; capillary zone electrophoresis; centrifugation; electrophoretic mobility; high performance liquid chromatography; isotachophoresis; liquid phase microextraction; micellar electrokinetic chromatography; microemulsion electrokinetic chromatography; nonhuman; solid phase extraction; tandem mass spectrometry; ultrasound; zeta potential; micelle; procedures
KW  -  Anti-Inflammatory Agents
KW  -  Non-Steroidal; Chromatography
KW  -  Micellar Electrokinetic Capillary; Isotachophoresis; Micelles; Water
TI  - Induced sample via transient isotachophoresis mediated with sweeping in micellar electrokinetic chromatography for the dual-stacking strategy of non-steroidal anti-inflammatory drugs in environmental water samples
ID  - scholars16080
AV  - none
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85141284367&doi=10.1016%2fj.chroma.2022.463616&partnerID=40&md5=c19b4402f72eb542788450dd1a157563
A1  - Semail, N.-F.
A1  - Keyon, A.S.A.
A1  - Saad, B.
A1  - Kamaruzaman, S.
A1  - Zain, N.N.M.
A1  - Lim, V.
A1  - Miskam, M.
A1  - Abdullah, W.N.W.
A1  - Raoov, M.
A1  - Yahaya, N.
JF  - Journal of Chromatography A
VL  - 1685
Y1  - 2022///
SN  - 00219673
PB  - Elsevier B.V.
ER  -