eprintid: 15964
rev_number: 2
eprint_status: archive
userid: 1
dir: disk0/00/01/59/64
datestamp: 2023-11-10 03:30:35
lastmod: 2023-11-10 03:30:35
status_changed: 2023-11-10 02:00:51
type: article
metadata_visibility: show
creators_name: Loganathan, K.
creators_name: Lv, J.
creators_name: Cropley, V.
creators_name: Ho, E.T.W.
creators_name: Zalesky, A.
title: Associations Between Delay Discounting and Connectivity of the Valuation-control System in Healthy Young Adults
ispublished: pub
keywords: adult; article; cohort analysis; connectome; control system; controlled study; decision making; delay discounting; executive function; female; functional connectivity; human; human experiment; lateral prefrontal cortex; major clinical study; male; posterior cingulate; posterior parietal cortex; reinforcement; reward; ventromedial prefrontal cortex; young adult; brain; nuclear magnetic resonance imaging; prefrontal cortex, Brain; Delay Discounting; Humans; Magnetic Resonance Imaging; Prefrontal Cortex; Reward; Young Adult
note: cited By 5
abstract: The process of valuation assists in determining if an object or course of action is rewarding. Delay discounting is the observed decay of a rewards� subjective value over time. Encoding the subjective value of rewards across a spectrum has been attributed to brain regions belonging to the valuation and executive control systems. The valuation system (VS) encodes reward value over short and long delays, influencing reinforcement learning and reward representation. The executive control system (ECS) becomes more active as choice difficulty increases, integrating contextual and mnemonic information with salience signals in the modulation of decision-making. Here, we aimed to identify resting-state functional connectivity-based patterns of the VS and ECS correlated with value-setting and delay discounting (outside-scanner paradigm) in a large (n = 992) cohort of healthy young adults from the Human Connectome Project (HCP). Results suggest the VS may be involved in value-setting of small, immediate rewards while the ECS may be involved in value-setting and delay discounting for large and small rewards over a range of delays. We observed magnitude sensitive connections involving the posterior cingulate cortex, time-sensitive connections with the ventromedial and lateral prefrontal cortex while connections involving the posterior parietal cortex appeared both magnitude- and time-sensitive. The ventromedial prefrontal cortex and posterior parietal cortex could act as �comparator� regions, weighing the value of small rewards against large rewards across various delay duration to aid in decision-making. © 2020 IBRO
date: 2021
publisher: Elsevier Ltd
official_url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097578191&doi=10.1016%2fj.neuroscience.2020.11.026&partnerID=40&md5=16d0240a6433766d99f5af363616d783
id_number: 10.1016/j.neuroscience.2020.11.026
full_text_status: none
publication: Neuroscience
volume: 452
pagerange: 295-310
refereed: TRUE
issn: 03064522
citation:   Loganathan, K. and Lv, J. and Cropley, V. and Ho, E.T.W. and Zalesky, A.  (2021) Associations Between Delay Discounting and Connectivity of the Valuation-control System in Healthy Young Adults.  Neuroscience, 452.  pp. 295-310.  ISSN 03064522