eprintid: 15940
rev_number: 2
eprint_status: archive
userid: 1
dir: disk0/00/01/59/40
datestamp: 2023-11-10 03:30:34
lastmod: 2023-11-10 03:30:34
status_changed: 2023-11-10 02:00:48
type: article
metadata_visibility: show
creators_name: Vasudevan, M.
creators_name: Tai, M.J.Y.
creators_name: Perumal, V.
creators_name: Gopinath, S.C.B.
creators_name: Murthe, S.S.
creators_name: Ovinis, M.
creators_name: Mohamed, N.M.
creators_name: Joshi, N.
title: Cellulose acetate-MoS2 nanopetal hybrid: A highly sensitive and selective electrochemical aptasensor of Troponin I for the early diagnosis of Acute Myocardial Infarction
ispublished: pub
keywords: Biomolecules; Biosensors; Electrochemical impedance spectroscopy; Layered semiconductors; Molybdenum compounds, Acute myocardial infarction; Acute myocardial infractions; Biomolecule detection; Cellulose acetates; Electrochemical aptasensor; Limit of detection; Screen printed electrodes; Sensing platforms, Diagnosis, Detection; Diagnosis; Impedance; Molybdenum Compounds; Reproducibility; Spectroscopy; Stability; Work
note: cited By 33
abstract: In this work, a novel aptamer-based CA-MoS2 hybrid biosensor was developed for diagnosis of Acute Myocardial Infraction (AMI). Specifically, a novel petal-like MoS2 nanoflower was used as the active material on the Screen-Printed Electrode (SPE) for AMI biomarker determination. The aptamer-based CA-MoS2�24 hybrid was able to attain a low limit of detection (LOD) and sensitivity to 10 fM at a linear range from 10 fM to 1 nM with good reproducibility based on an electrochemical impedance spectroscopy and a ~4 folds higher selectivity of troponin I compared to the signal from other biomolecules in human serum, retaining a 91 stability after 6 weeks. This novel CA-MoS2 aptamer-based biosensor with a 2.3 RSD value has the potential to revolutionize medical diagnosis by conducting multiple biomolecule detection on a single sensing platform. © 2021 Taiwan Institute of Chemical Engineers
date: 2021
publisher: Taiwan Institute of Chemical Engineers
official_url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099612127&doi=10.1016%2fj.jtice.2021.01.016&partnerID=40&md5=e29a4a650afde3565e99a03578771a2e
id_number: 10.1016/j.jtice.2021.01.016
full_text_status: none
publication: Journal of the Taiwan Institute of Chemical Engineers
volume: 118
pagerange: 245-253
refereed: TRUE
issn: 18761070
citation:   Vasudevan, M. and Tai, M.J.Y. and Perumal, V. and Gopinath, S.C.B. and Murthe, S.S. and Ovinis, M. and Mohamed, N.M. and Joshi, N.  (2021) Cellulose acetate-MoS2 nanopetal hybrid: A highly sensitive and selective electrochemical aptasensor of Troponin I for the early diagnosis of Acute Myocardial Infarction.  Journal of the Taiwan Institute of Chemical Engineers, 118.  pp. 245-253.  ISSN 18761070