TY - JOUR JF - Journal of the Taiwan Institute of Chemical Engineers PB - Taiwan Institute of Chemical Engineers SN - 18761070 TI - Cellulose acetate-MoS2 nanopetal hybrid: A highly sensitive and selective electrochemical aptasensor of Troponin I for the early diagnosis of Acute Myocardial Infarction VL - 118 A1 - Vasudevan, M. A1 - Tai, M.J.Y. A1 - Perumal, V. A1 - Gopinath, S.C.B. A1 - Murthe, S.S. A1 - Ovinis, M. A1 - Mohamed, N.M. A1 - Joshi, N. N2 - In this work, a novel aptamer-based CA-MoS2 hybrid biosensor was developed for diagnosis of Acute Myocardial Infraction (AMI). Specifically, a novel petal-like MoS2 nanoflower was used as the active material on the Screen-Printed Electrode (SPE) for AMI biomarker determination. The aptamer-based CA-MoS2â??24 hybrid was able to attain a low limit of detection (LOD) and sensitivity to 10 fM at a linear range from 10 fM to 1 nM with good reproducibility based on an electrochemical impedance spectroscopy and a ~4 folds higher selectivity of troponin I compared to the signal from other biomolecules in human serum, retaining a 91 stability after 6 weeks. This novel CA-MoS2 aptamer-based biosensor with a 2.3 RSD value has the potential to revolutionize medical diagnosis by conducting multiple biomolecule detection on a single sensing platform. © 2021 Taiwan Institute of Chemical Engineers N1 - cited By 33 Y1 - 2021/// EP - 253 SP - 245 UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099612127&doi=10.1016%2fj.jtice.2021.01.016&partnerID=40&md5=e29a4a650afde3565e99a03578771a2e ID - scholars15940 KW - Biomolecules; Biosensors; Electrochemical impedance spectroscopy; Layered semiconductors; Molybdenum compounds KW - Acute myocardial infarction; Acute myocardial infractions; Biomolecule detection; Cellulose acetates; Electrochemical aptasensor; Limit of detection; Screen printed electrodes; Sensing platforms KW - Diagnosis KW - Detection; Diagnosis; Impedance; Molybdenum Compounds; Reproducibility; Spectroscopy; Stability; Work AV - none ER -