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primary topic: Cellulose acetate-MoS2 nanopetal hybrid: A highly sensitive and selective electrochemical aptasensor of Troponin I for the early diagnosis of Acute Myocardial Infarction

Cellulose acetate-MoS2 nanopetal hybrid: A highly sensitive and selective electrochemical aptasensor of Troponin I for the early diagnosis of Acute Myocardial Infarction
type: AcademicArticle
type: Article
abstract: In this work, a novel aptamer-based CA-MoS2 hybrid biosensor was developed for diagnosis of Acute Myocardial Infraction (AMI). Specifically, a novel petal-like MoS2 nanoflower was used as the active material on the Screen-Printed Electrode (SPE) for AMI biomarker determination. The aptamer-based CA-MoS2â��24 hybrid was able to attain a low limit of detection (LOD) and sensitivity to 10 fM at a linear range from 10 fM to 1 nM with good reproducibility based on an electrochemical impedance spectroscopy and a ~4 folds higher selectivity of troponin I compared to the signal from other biomolecules in human serum, retaining a 91 stability after 6 weeks. This novel CA-MoS2 aptamer-based biosensor with a 2.3 RSD value has the potential to revolutionize medical diagnosis by conducting multiple biomolecule detection on a single sensing platform. © 2021 Taiwan Institute of Chemical Engineers
date: 2021
volume: 118
is part of: Journal of the Taiwan Institute of Chemical Engineers
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository

Taiwan Institute of Chemical Engineers
type: Organization

Journal of the Taiwan Institute of Chemical Engineers
type: Collection
issn: 18761070

M. Ovinis
type: Person
given name: M.
family name: Ovinis

N. Joshi
type: Person
given name: N.
family name: Joshi

N.M. Mohamed
type: Person
given name: N.M.
family name: Mohamed

V. Perumal
type: Person
given name: V.
family name: Perumal

M. Vasudevan
type: Person
given name: M.
family name: Vasudevan

S.C.B. Gopinath
type: Person
given name: S.C.B.
family name: Gopinath

M.J.Y. Tai
type: Person
given name: M.J.Y.
family name: Tai

S.S. Murthe
type: Person
given name: S.S.
family name: Murthe

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primary topic: Cellulose acetate-MoS2 nanopetal hybrid: A highly sensitive and selective electrochemical aptasensor of Troponin I for the early diagnosis of Acute Myocardial Infarction