%0 Journal Article
%@ 18761070
%A Vasudevan, M.
%A Tai, M.J.Y.
%A Perumal, V.
%A Gopinath, S.C.B.
%A Murthe, S.S.
%A Ovinis, M.
%A Mohamed, N.M.
%A Joshi, N.
%D 2021
%F scholars:15940
%I Taiwan Institute of Chemical Engineers
%J Journal of the Taiwan Institute of Chemical Engineers
%K Biomolecules; Biosensors; Electrochemical impedance spectroscopy; Layered semiconductors; Molybdenum compounds, Acute myocardial infarction; Acute myocardial infractions; Biomolecule detection; Cellulose acetates; Electrochemical aptasensor; Limit of detection; Screen printed electrodes; Sensing platforms, Diagnosis, Detection; Diagnosis; Impedance; Molybdenum Compounds; Reproducibility; Spectroscopy; Stability; Work
%P 245-253
%R 10.1016/j.jtice.2021.01.016
%T Cellulose acetate-MoS2 nanopetal hybrid: A highly sensitive and selective electrochemical aptasensor of Troponin I for the early diagnosis of Acute Myocardial Infarction
%U https://khub.utp.edu.my/scholars/15940/
%V 118
%X In this work, a novel aptamer-based CA-MoS2 hybrid biosensor was developed for diagnosis of Acute Myocardial Infraction (AMI). Specifically, a novel petal-like MoS2 nanoflower was used as the active material on the Screen-Printed Electrode (SPE) for AMI biomarker determination. The aptamer-based CA-MoS2�24 hybrid was able to attain a low limit of detection (LOD) and sensitivity to 10 fM at a linear range from 10 fM to 1 nM with good reproducibility based on an electrochemical impedance spectroscopy and a ~4 folds higher selectivity of troponin I compared to the signal from other biomolecules in human serum, retaining a 91 stability after 6 weeks. This novel CA-MoS2 aptamer-based biosensor with a 2.3 RSD value has the potential to revolutionize medical diagnosis by conducting multiple biomolecule detection on a single sensing platform. © 2021 Taiwan Institute of Chemical Engineers
%Z cited By 33