relation: https://khub.utp.edu.my/scholars/15940/ title: Cellulose acetate-MoS2 nanopetal hybrid: A highly sensitive and selective electrochemical aptasensor of Troponin I for the early diagnosis of Acute Myocardial Infarction creator: Vasudevan, M. creator: Tai, M.J.Y. creator: Perumal, V. creator: Gopinath, S.C.B. creator: Murthe, S.S. creator: Ovinis, M. creator: Mohamed, N.M. creator: Joshi, N. description: In this work, a novel aptamer-based CA-MoS2 hybrid biosensor was developed for diagnosis of Acute Myocardial Infraction (AMI). Specifically, a novel petal-like MoS2 nanoflower was used as the active material on the Screen-Printed Electrode (SPE) for AMI biomarker determination. The aptamer-based CA-MoS2�24 hybrid was able to attain a low limit of detection (LOD) and sensitivity to 10 fM at a linear range from 10 fM to 1 nM with good reproducibility based on an electrochemical impedance spectroscopy and a ~4 folds higher selectivity of troponin I compared to the signal from other biomolecules in human serum, retaining a 91 stability after 6 weeks. This novel CA-MoS2 aptamer-based biosensor with a 2.3 RSD value has the potential to revolutionize medical diagnosis by conducting multiple biomolecule detection on a single sensing platform. © 2021 Taiwan Institute of Chemical Engineers publisher: Taiwan Institute of Chemical Engineers date: 2021 type: Article type: PeerReviewed identifier: Vasudevan, M. and Tai, M.J.Y. and Perumal, V. and Gopinath, S.C.B. and Murthe, S.S. and Ovinis, M. and Mohamed, N.M. and Joshi, N. (2021) Cellulose acetate-MoS2 nanopetal hybrid: A highly sensitive and selective electrochemical aptasensor of Troponin I for the early diagnosis of Acute Myocardial Infarction. Journal of the Taiwan Institute of Chemical Engineers, 118. pp. 245-253. ISSN 18761070 relation: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099612127&doi=10.1016%2fj.jtice.2021.01.016&partnerID=40&md5=e29a4a650afde3565e99a03578771a2e relation: 10.1016/j.jtice.2021.01.016 identifier: 10.1016/j.jtice.2021.01.016