@article{scholars15940, pages = {245--253}, volume = {118}, doi = {10.1016/j.jtice.2021.01.016}, year = {2021}, note = {cited By 33}, publisher = {Taiwan Institute of Chemical Engineers}, title = {Cellulose acetate-MoS2 nanopetal hybrid: A highly sensitive and selective electrochemical aptasensor of Troponin I for the early diagnosis of Acute Myocardial Infarction}, journal = {Journal of the Taiwan Institute of Chemical Engineers}, author = {Vasudevan, M. and Tai, M. J. Y. and Perumal, V. and Gopinath, S. C. B. and Murthe, S. S. and Ovinis, M. and Mohamed, N. M. and Joshi, N.}, issn = {18761070}, keywords = {Biomolecules; Biosensors; Electrochemical impedance spectroscopy; Layered semiconductors; Molybdenum compounds, Acute myocardial infarction; Acute myocardial infractions; Biomolecule detection; Cellulose acetates; Electrochemical aptasensor; Limit of detection; Screen printed electrodes; Sensing platforms, Diagnosis, Detection; Diagnosis; Impedance; Molybdenum Compounds; Reproducibility; Spectroscopy; Stability; Work}, abstract = {In this work, a novel aptamer-based CA-MoS2 hybrid biosensor was developed for diagnosis of Acute Myocardial Infraction (AMI). Specifically, a novel petal-like MoS2 nanoflower was used as the active material on the Screen-Printed Electrode (SPE) for AMI biomarker determination. The aptamer-based CA-MoS2{\^a}??24 hybrid was able to attain a low limit of detection (LOD) and sensitivity to 10 fM at a linear range from 10 fM to 1 nM with good reproducibility based on an electrochemical impedance spectroscopy and a {\texttt{\char126}}4 folds higher selectivity of troponin I compared to the signal from other biomolecules in human serum, retaining a 91 stability after 6 weeks. This novel CA-MoS2 aptamer-based biosensor with a 2.3 RSD value has the potential to revolutionize medical diagnosis by conducting multiple biomolecule detection on a single sensing platform. {\^A}{\copyright} 2021 Taiwan Institute of Chemical Engineers}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099612127&doi=10.1016\%2fj.jtice.2021.01.016&partnerID=40&md5=e29a4a650afde3565e99a03578771a2e} }