%0 Conference Paper
%A Rahim, N.Y.
%A Md Zuki, N.N.
%A Jumbri, K.
%A Mohamad, S.
%A Abdul Manan, N.S.
%A Sidek, N.
%A Boon, Y.H.
%A Ramachandran, M.R.
%D 2021
%F scholars:15549
%I Springer Science and Business Media B.V.
%P 131-145
%R 10.1007/978-981-16-4513-6₁₂
%T Inclusion Complexes of β-Cyclodextrin/Pioglitazone and β-Cyclodextrin-Ionic Liquid/Pioglitazone: Spectroscopic Methods Combined with Molecular Docking Studies
%U https://khub.utp.edu.my/scholars/15549/
%X The complexes of β-cyclodextrin/pioglitazone and β-cyclodextrin-ionic liquid/pioglitazone were prepared by kneading method. Characterization using FT-IR, thermogravimetric analysis and NMR had proven the formation of the complexes. From 1H NMR determination, pioglitazone is proven to form hydrogen bonding and inclusion complex with native β-cyclodextrin and β-cyclodextrin-ionic liquid. The molecular docking also reveals the same interaction involved for the formation of complexes β-cyclodextrin/pioglitazone and β-cyclodextrin-ionic liquid/pioglitazone. The binding energy obtained from molecular studies for the complex of β-cyclodextrin-ionic liquid/pioglitazone is higher than the binding energy of β-cyclodextrin/pioglitazone. © 2021, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
%Z cited By 0; Conference of 6th International Conference on Fundamental and Applied Sciences, ICFAS 2020 ; Conference Date: 13 July 2021 Through 15 July 2021; Conference Code:270909