TY  - JOUR
ID  - scholars14998
N2  - Over the years, various models have been proposed to explain the psychology and biology of drug addiction, built primarily around the habit and compulsion models. Recent research indicates drug addiction may be goal-directed, motivated by excessive valuation of drugs. Drug consumption may initially occur for the sake of pleasure but may transition to a means of escaping withdrawal, stress and negative emotions. In this hypothetical paper, we propose a value-based neurobiological model for drug addiction. We posit that during dependency, the value-based decision-making system in the brain is not inactive but has instead prioritized drugs as the reward of choice. In support of this model, we consider the role of valuation in choice, its influence on pleasure and punishment, and how valuation is contrasted in impulsive and compulsive behaviours. We then discuss the neurobiology of value, beginning with the dopaminergic system and its relationship with incentive salience before moving to brain-wide networks involved in valuation, control and prospection. These value-based neurobiological components are then integrated into the cycle of addiction as we consider the development of drug dependency from a valuation perspective. We conclude with a discussion of cognitive interventions utilizing value-based decision-making, highlighting not just advances in recalibrating the valuation system to focus on non-drug rewards, but also areas for improvement in refining this approach. © 2021 Elsevier Ltd
VL  - 116
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099178656&doi=10.1016%2fj.addbeh.2021.106816&partnerID=40&md5=db3d79502161fd0dba09bc843e79594d
SN  - 03064603
JF  - Addictive Behaviors
PB  - Elsevier Ltd
A1  - Loganathan, K.
A1  - Ho, E.T.W.
KW  - dopamine; dopamine 2 receptor; dopamine 3 receptor
KW  -  amygdala; attention; autoregulation; brain; compulsion; coping behavior; decision making; dopaminergic system; dorsal anterior cingulate cortex; drug dependence; emotion; episodic memory; euphoria; functional magnetic resonance imaging; human; impulsiveness; intervention study; lateral prefrontal cortex; learning; mental function; nuclear magnetic resonance imaging; orbital cortex; positron emission tomography; posterior parietal cortex; reward; Short Survey; task performance; value; addiction; brain; motivation
KW  -  Behavior
KW  -  Addictive; Brain; Humans; Motivation; Reinforcement
KW  -  Psychology; Reward; Substance-Related Disorders
Y1  - 2021///
TI  - Value, drug addiction and the brain
N1  - cited By 5
AV  - none
ER  -