@article{scholars14942,
            year = {2021},
         journal = {ACS Applied Materials and Interfaces},
       publisher = {American Chemical Society},
           pages = {19745--19755},
          volume = {13},
            note = {cited By 37},
          number = {17},
             doi = {10.1021/acsami.1c03111},
           title = {Biocompatible Ionic Liquid-Mediated Micelles for Enhanced Transdermal Delivery of Paclitaxel},
            issn = {19448244},
          author = {Ali, M. K. and Moshikur, R. M. and Wakabayashi, R. and Moniruzzaman, M. and Goto, M.},
        abstract = {Chemotherapeutic cytotoxic agents such as paclitaxel (PTX) are considered essential for the treatment of various cancers. However, PTX injection is associated with severe systemic side effects and high rates of patient noncompliance. Micelle formulations (MFs) are nano-drug delivery systems that offer a solution to these problems. Herein, we report an advantageous carrier for the transdermal delivery of PTX comprising a new MF that consists of two biocompatible surfactants: cholinium oleate (ChoOle), which is a surface-active ionic liquid (SAIL), and sorbitan monolaurate (Span-20). A solubility assessment confirmed that PTX was readily solubilized in the SAIL-based micelles via multipoint hydrogen bonding and cation-{\"I}?and {\"I}?-{\"I}?interactions between PTX and SAILChoOle. Dynamic light scattering (DLS) and transmission electron microscopy revealed that in the presence of PTX, the MF formed spherical PTX-loaded micelles that were well-distributed in the range 8.7-25.3 nm. According to DLS, the sizes and size distributions of the micelle droplets did not change significantly over the entire storage period, attesting to their physical stability. In vitro transdermal assessments using a Franz diffusion cell revealed that the MF absorbed PTX 4 times more effectively than a Tween 80-based formulation and 6 times more effectively than an ethanol-based formulation. In vitro and in vivo skin irritation tests revealed that the new carrier had a negligible toxicity profile compared with a conventional ionic liquid-based carrier. Based on these findings, we believe that the SAILChoOle-based MF has potential as a biocompatible nanocarrier for the effective transdermal delivery of poorly soluble chemotherapeutics such as PTX. {\^A}{\copyright}},
        keywords = {Biocompatibility; Controlled drug delivery; Dynamic light scattering; High resolution transmission electron microscopy; Hydrogen bonds; Ionic liquids; Oleic acid; Targeted drug delivery, Biocompatible surfactants; Cytotoxic agents; Drug delivery system; Franz diffusion cells; Physical stability; Skin irritation; Surface active ionic liquids; Transdermal delivery, Micelles, antineoplastic agent; biomaterial; ionic liquid; paclitaxel; surfactant, animal; Bagg albino mouse; chemistry; cutaneous drug administration; drug delivery system; female; infrared spectroscopy; micelle; mouse; proton nuclear magnetic resonance; skin absorption, Administration, Cutaneous; Animals; Antineoplastic Agents, Phytogenic; Biocompatible Materials; Drug Delivery Systems; Female; Ionic Liquids; Mice; Mice, Inbred BALB C; Micelles; Paclitaxel; Proton Magnetic Resonance Spectroscopy; Skin Absorption; Spectroscopy, Fourier Transform Infrared; Surface-Active Agents},
             url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105906191&doi=10.1021\%2facsami.1c03111&partnerID=40&md5=efab35b942c2096a0f97c1bbd89ae10d}
}