%0 Journal Article
%@ 01680102
%A Loganathan, K.
%A Lv, J.
%A Cropley, V.
%A Zalesky, A.
%A Ho, E.T.W.
%D 2021
%F scholars:14216
%I Elsevier Ireland Ltd
%J Neuroscience Research
%K alcohol; cannabis; central stimulant agent; cocaine; illicit drug; opiate; psychedelic agent; sedative agent; drug, adult; Article; cannabis use; connectome; controlled study; drug use; evidence based practice; executive function; female; functional connectivity; functional magnetic resonance imaging; head movement; human; major clinical study; male; medical information system; multiple drug abuse; neuroscience; population; signal noise ratio; substance use; tobacco use; valuation control complex; valuation system connectivity; young adult; brain; drug dependence; nuclear magnetic resonance imaging, Brain; Executive Function; Humans; Magnetic Resonance Imaging; Pharmaceutical Preparations; Substance-Related Disorders; Young Adult
%P 114-120
%R 10.1016/j.neures.2021.06.006
%T Valuation system connectivity is correlated with poly-drug use in young adults
%U https://khub.utp.edu.my/scholars/14216/
%V 173
%X Poly-drug consumption contributes to fatal overdose in more than half of all poly-drug users. Analyzing decision-making networks may give insight into the motivations behind poly-drug use. We correlated average functional connectivity of the valuation system (VS), executive control system (ECS) and valuation-control complex (VCC) in a large population sample (n = 992) with drug use behaviour. VS connectivity is correlated with sedative use, ECS connectivity is separately correlated with hallucinogens and opiates. Network connectivity is also correlated with drug use via two-way interactions with other substances including alcohol and tobacco. These preliminary findings can contribute to our understanding of the common combinations of substance co-use and associated neural patterns. © 2021 Elsevier B.V. and Japan Neuroscience Society
%Z cited By 2