%T Functional near-infrared spectroscopy during the verbal fluency task of English-Speaking adults with mood disorders: A preliminary study
%I Churchill Livingstone
%V 94
%A S.F. Husain
%A R.S. McIntyre
%A T.-B. Tang
%A M.H. Abd Latif
%A B.X. Tran
%A V.G. Linh
%A T.P.N. Thao
%A C.S. Ho
%A R.C. Ho
%P 94-101
%K deoxyhemoglobin; oxyhemoglobin, adult; age distribution; aged; area under the curve; Article; brain function; brain region; clinical article; cognition; controlled study; educational status; English (language); ethnicity; female; frontal lobe; functional near-infrared spectroscopy; gender; hemodynamics; human; male; mood disorder; predictive value; prefrontal cortex; receiver operating characteristic; speech and language assessment; task performance; verbal fluency task; bipolar disorder; major depression; mood disorder; near infrared spectroscopy; neuropsychological test, Adult; Bipolar Disorder; Depressive Disorder, Major; Humans; Mood Disorders; Neuropsychological Tests; Spectroscopy, Near-Infrared
%X Functional near-infrared spectroscopy (fNIRS) provides a direct and objective assessment of cerebral cortex function. It may be used to determine neurophysiological differences between psychiatric disorders with overlapping symptoms, such as major depressive disorder (MDD) and bipolar disorder (BD). Therefore, this preliminary study aimed to compare fNIRS signals during the verbal fluency task (VFT) of English-speaking healthy controls (HC), patients with MDD and patients with BD. Fifteen HCs, 15 patients with MDD and 15 patients with BD were recruited. Groups were matched for age, gender, ethnicity and education. Relative oxy-haemoglobin and deoxy-haemoglobin changes in the frontotemporal cortex was monitored with a 52-channel fNIRS system. Integral values of the frontal and temporal regions were derived as a measure cortical haemodynamic response magnitude. Both patient groups had lower frontal and temporal region integral values than HCs, and patients with MDD had lower frontal region integral value than patients with BD. Moreover, patients could be differentiated from HCs using the frontal and temporal integral values, and patient groups could be differentiated using the frontal region integral values. VFT performance, clinical history and symptom severity were not associated with integral values. These results suggest that prefrontal cortex haemodynamic dysfunction occurs in mood disorders, and it is more extensive in MDD than BD. The fNIRS-VFT paradigm may be a potential tool for differentiating MDD from BD in clinical settings, and these findings need to be verified in a larger sample of English-speaking patients with mood disorders. © 2021 Elsevier Ltd
%O cited By 13
%L scholars14192
%J Journal of Clinical Neuroscience
%D 2021
%R 10.1016/j.jocn.2021.10.009